Evidence map›Paper›PMID 39755505›Full record

ArticleTrends in parasitology2025

Malaria monoclonals block brain binding.

Stephen J Rogerson, Isobel S Walker, Elizabeth H Aitken

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen J RogersonDepartment of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia. Electronic address: sroger@unimelb.edu.au.
Isobel S WalkerDepartment of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.
Elizabeth H AitkenDepartment of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.

Funding

Identifying functional antibody responses that protect against malaria in childrenR01AI165595 · NIAID · MICHIGAN STATE UNIVERSITY · PI Karl Boynton Seydel · 2022 to 2026
$2.3M
NIAID NIH HHS R01 AI165595
6 · The paper itself

Abstract

In Plasmodium falciparum malaria, infected cells accumulate in blood vessels of organs, including the brain. Recently, Reyes et al. identified monoclonal antibodies that stop infected cells from binding to the endothelial protein C receptor (EPCR) in a model of brain blood vessels. EPCR-blocking monoclonals could form the basis of new treatments for severe malaria.

Indexed as

Antibodies, MonoclonalBrainMalaria, FalciparumPlasmodium falciparumAnimalsEndothelial Protein C ReceptorHumansAntibodies, MonoclonalEndothelial Protein C Receptorcerebral malariaendothelial protein C receptormonoclonal antibodyP. falciparum erythrocyte membrane protein 1Plasmodium falciparum

Identifiers

PMID39755505
PMCPMC11802285

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.