Evidence map›Paper›PMID 39755810›Full record

ArticleArchives of dermatological research2025

Causal relationship between psoriasis and sudden deafness: a Mendelian randomization study.

Linrong Wu, Yiming Shen, Junjun Zhang, Zhisen Shen, Tian Li

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Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Linrong WuDepartment of Otolaryngology, Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, 315100, China.
Yiming ShenOtology and Skull Base Surgery, National Health Commission Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200000, China.
Junjun ZhangDepartment of Trauma Surgery, Ningbo Yinzhou No.2 Hospital, Ningbo, 315100, China. 604988147@qq.com.
Zhisen ShenDepartment of Otolaryngology, Head and Neck Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, 315100, China.
Tian LiTianjin Medical University, Tianjin, 300102, China. fmmult@foxmail.com.

Funding

Ningbo Top Medical and Health Research Program 2023030514
6 · The paper itself

Abstract

objectiveThis study aims to investigate the genetic link between psoriasis and sudden sensorineural hearing loss (SSNHL).

methodsFrom a genetic standpoint, this study further highlighted the connection between psoriasis and SSNHL. Single nucleotide polymorphisms (SNPs) connected to SSNHL could be found using a genome-wide association study from the IEU OpenGWAS project website. In addition, the inverse variance weighted (IVW) technique was used to evaluate the connection between psoriasis and SSNHL.

resultsAccording to Mendelian randomization analysis, IVW supported the causal relationship between psoriasis and SSNHL (OR = 808.86, 95%CI 3.32 ~ 196942.07, P = 0.02). In the sensitivity analysis, there was no heterogeneity or horizontal pleiotropy, and the Leave-one-out analysis suggested that the causal effect was robust.The results of MR-Egger (Q = 13.53, P = 0.76) and IVW (Q = 14.73, P = 0.74) showed that there was no heterogeneity in SNPs, and the results were reliable. We also performed a horizontal pleiotropic analysis (P = 0.29), which showed that there was no horizontal pleiotropy and no confounding factors in the study.

conclusionFrom a genetic perspective, there is a causal relationship between psoriasis and an increased risk of sudden sensorineural hearing loss.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyHearing Loss, SuddenMendelian Randomization AnalysisPolymorphism, Single NucleotidePsoriasisHearing Loss, SensorineuralHumansRisk FactorsMendelian randomizationPsoriasisSingle nucleotide polymorphismSudden deafness

Identifiers

PMID39755810

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.