Evidence map›Paper›PMID 39755823›Full record

ArticleApoptosis : an international journal on programmed cell death2025

Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia.

Na Liu, Yuzhuo Sun, Jieyun Liu, Yangyang Zhang, Xinyao Yi, Wenhui Yan, Xin Cui, Tingli Guo, Wenzhuo Zhao, Shengli Han and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Na LiuDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Yuzhuo SunDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Jieyun LiuDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Yangyang ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Xinyao YiDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Wenhui YanDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Xin CuiDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Tingli GuoDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Wenzhuo ZhaoDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China.
Shengli HanSchool of Pharmacy, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Weina MaSchool of Pharmacy, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Yapeng CaoKey Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, 710061, China. yapengcaopku@xjtu.edu.cn.
Lina ChenDepartment of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, 710061, China. chenlin@mail.xjtu.edu.cn.

Funding

Basic & Clinical Sciences Integration Innovation Project of Xi'an Jiaotong University YXJLRH2022018National Natural Science Foundation of China 82000072National Natural Science Foundation of China 82301365Natural Science Basic Research Program of Shaanxi Province 2023-JC-QN-0921Research Project of Shaanxi Administration of Traditional Chinese Medicine SZY-KJCYC-2023-008The China Postdoctoral Science Foundation 2020M673425
6 · The paper itself

Abstract

Tangerine peel is a traditional Chinese herb and has been widely applied in foods and medicine for its multiple pharmacological effects. Erythropoietin receptor (EPOR), a member of the cytokine receptor family, is widely expressed in multiple tissues in especial kidney and plays protective effects in adverse physiological and pathological conditions. We hypothesized that it might be EPOR agonists existing in Tangerine peel bring such renal benefits. To test our hypothesis, an EPOR/cell membrane chromatography (CMC)-high performance liquid chromatography (HPLC)-mass spectrometry (MS) analytical system was developed to screen EPOR targeted compounds from tangerine peel extra out. A fraction was retained on the EPOR/CMC column, separated, and further identified as nobiletin. Frontal analysis, non-linear chromatography, and molecular docking assay were applied to determine the binding force and sites between nobiletin and EPOR. Intracellular Ca

Indexed as

FlavonesKidneyMesangial CellsReceptors, ErythropoietinApoptosisCell HypoxiaCell LineCell SurvivalHumansMolecular Docking SimulationSignal TransductionFlavonesnobiletinReceptors, ErythropoietinApoptosisCell membrane chromatographyEPORJAK2-STAT5Nobiletin

Identifiers

PMID39755823

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.