ArticleBreast cancer research and treatment2025
Demographic and clinical trends of young breast cancer patients from the national cancer database: disproportionate effect on minority populations.
Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between Climate Change and Breast Cancer and Its Management and Preventative Implications in South Africa.International journal of environmental research and public health · 2025Pooled it
- Trends in Breast and Axillary Operations in Young Patients with Operable Breast Cancer from the National Cancer Database (NCDB): De-escalation of Axillary Surgery and Increased Use of Radiation.Annals of surgical oncology · 2026Article
- Breast Cancer Survival in Asian American Patients.JAMA network open · 2026Article
- Personalized survival prediction in young Asian American breast cancer.Gland surgery · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere is an increasing incidence of young breast cancer (YBC) patients with uncertainty surrounding the factors and patterns that are contributing.
methodsWe obtained characteristics and survival data from 206,156 YBC patients (≤ 40 years of age) diagnosed between 2005 and 2019 from the National Cancer Database (NCDB). Patients were subdivided into two comparison groups based on year of diagnosis (2005-2009, Old vs. 2015-2019, New group). A Chi-square test of independence was employed to measure the changes. Cox proportional hazards model was used to explore the variables influencing overall survival (OS).
resultsComparison between Old (55,397 patients) and New groups (67,930 patients) showed an increase in the proportion of Hispanic (8.4% vs 10.0%), Black (16.0% vs 16.6%), and Asian (4.8% vs 6.7%) populations. In the New group, black patients had a significantly worse OS, p < 0.001. Additionally, there was a reduction in the proportion of patients with private insurance (43,940 (81.7%) vs 51,104 (76.4%)) and an increase in patients with Medicaid (5,893 (11.0%) vs 10,694 (16.0%)). Finally, there was a significant increase in hormone positive disease (35,142 (70.0%) vs 49,409 (75.8%), p = < 0.001).
conclusionsWithin YBC patients, the proportion of underrepresented and underserved population is increasing, with an impact on OS. We also see an increase in hormone positive disease. Awareness of these at-risk populations is important for early identification of breast cancer and mitigation of poorer outcomes. Also, there are increasing rates of hormone positive disease which can cause substantial personal and societal implications, such as impacts on family planning and early menopause.
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