Evidence map›Paper›PMID 39756002›Full record

ReviewCurrent microbiology2025

The Translation Initiation Factor eIF2Bα Regulates Development, Stress Response, Amylase Production, and Kojic Acid Synthesis in the Fungus Aspergillus oryzae.

Yiling Liu, Zixin Chen, Chaofeng Chang, Yifen Lin, Guiyi Zheng, Feng Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yiling Liu *Engineering Technological Center of Fungus Active Substances of Fujian Province, College of Biological Sciences and Technology, Minnan Normal University, Zhangzhou, 363000, China.
Zixin Chen *Engineering Technological Center of Fungus Active Substances of Fujian Province, College of Biological Sciences and Technology, Minnan Normal University, Zhangzhou, 363000, China.
Chaofeng ChangEngineering Technological Center of Fungus Active Substances of Fujian Province, College of Biological Sciences and Technology, Minnan Normal University, Zhangzhou, 363000, China.
Yifen LinEngineering Technological Center of Fungus Active Substances of Fujian Province, College of Biological Sciences and Technology, Minnan Normal University, Zhangzhou, 363000, China.
Guiyi ZhengEngineering Technological Center of Fungus Active Substances of Fujian Province, College of Biological Sciences and Technology, Minnan Normal University, Zhangzhou, 363000, China.
Feng ZhangEngineering Technological Center of Fungus Active Substances of Fujian Province, College of Biological Sciences and Technology, Minnan Normal University, Zhangzhou, 363000, China. fzhang@mnnu.edu.cn.

Funding

Minnan Normal University No. KJ19023Natural Science Foundation of Fujian Province No. 2021J011000
6 · The paper itself

Abstract

Translation initiation, which involves numerous protein factors and coordinated control steps, represents the most complicated process during eukaryotic translation. However, the roles of eukaryotic translation initiation factor (eIF) in filamentous fungi are not well clarified. In this study, we investigated the function of eIF2Bα in Aspergillus oryzae, an industrially important filamentous fungus. The ΔeIF2Bα mutants showed slow colony growth and decreased conidia production, suggesting the critical roles of eIF2Bα in the growth and development of A. oryzae. In addition, the loss of eIF2Bα significantly impaired the ability to produce amylase and kojic acid, indicating the involvement of eIF2Bα in the amylase synthesis and secondary metabolite production. Interestingly, the elimination of eIF2Bα improved the tolerance of A. oryzae to diverse adverse stresses, including endoplasmic reticulum stress, oxidative stress, cell wall-perturbing stress, and cell membrane-damaging stress. Overall, our results indicate that eIF2Bα is a crucial regulator of growth, development, stress response, amylase production, and kojic acid synthesis in A. oryzae.

Indexed as

AmylasesAspergillus oryzaeFungal ProteinsPyronesEukaryotic Initiation Factor-2Gene Expression Regulation, FungalKeto AcidsSpores, FungalStress, PhysiologicalAmylasesEukaryotic Initiation Factor-2Fungal ProteinsKeto Acidskojic acidPyrones

Identifiers

PMID39756002

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.