Evidence map›Paper›PMID 39756495›Full record

ArticleDevelopmental biology2025

Ancient emergence of neuronal heterogeneity in the enteric nervous system of jawless vertebrates.

Brittany M Edens, Jason Lin, Marianne E Bronner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brittany M EdensDivision of Biology and Biological Engineering, California Institute of Technology, 91125, Pasadena, CA, USA.
Jason LinDivision of Biology and Biological Engineering, California Institute of Technology, 91125, Pasadena, CA, USA.
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, 91125, Pasadena, CA, USA. Electronic address: mbronner@caltech.edu.

Funding

Progressive acquisition of novel neural crest derivatives along the neural axis during vertebrate evolutionR35NS111564 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2019 to 2026
$5.0M
Transcriptional regulation of neuronal cell lineage decisions in the developing enteric nervous systemR01HD105604 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2022 to 2026
$2.6M
Analysis of transcriptional priming of progenitors in the vertebrate neural plate borderF32HD106627 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI EDENS, BRITTANY MEGAN · 2021 to 2024
$209k
NICHD NIH HHS F32 HD106627NICHD NIH HHS R01 HD105604NINDS NIH HHS R35 NS111564
6 · The paper itself

Abstract

While the enteric nervous system (ENS) of jawed vertebrates is largely derived from the vagal neural crest, lamprey are jawless vertebrates that lack the vagal neural crest, yet possess enteric neurons derived from late-migrating Schwann cell precursors. To illuminate homologies between the ENS of jawed and jawless vertebrates, here we examine the diversity and distribution of neuronal subtypes within the intestine of the sea lamprey during late embryonic and ammocete stages. In addition to previously described 5-HT-immunoreactive serotonergic neurons, we identified NOS

Indexed as

Enteric Nervous SystemNeuronsPetromyzonAnimalsIntestinesLampreysNeural CrestEnteric nervous system (ENS)Evolutionary developmentNeural crestPeripheral nervous system (PNS)Schwann cell precursor (SCP)Vertebrate evolution

Identifiers

PMID39756495
PMCPMC11830548

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.