Evidence map›Paper›PMID 39757262›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

In Vitro Investigation of the Anti-Hepatocellular Carcinoma Activity of Peptides Derived From Quinoa (Chenopodium quinoa Willd) Bran.

Jiangying Shi, Cai Bi, Shuhua Shan, Mengyun Zhao, Jiarong Li, Xiaoyan Hao, Nifei Wang, Zhuoyu Li

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiangying Shi *Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, 030006, Taiyuan, China.
Cai Bi *Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, 030006, Taiyuan, China.
Shuhua ShanInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, 030006, Taiyuan, China.
Mengyun ZhaoInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, 030006, Taiyuan, China.
Jiarong LiInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, 030006, Taiyuan, China.
Xiaoyan HaoCollege of Life Science, Shanxi University, 030006, Taiyuan, China.
Nifei WangInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, 030006, Taiyuan, China.
Zhuoyu Li *Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, 030006, Taiyuan, China. lzy@sxu.edu.cn.

Funding

National Natural Science Foundation of China No. 32072220National Natural Science Foundation of China No. 32270420National Natural Science Foundation of China Regional Innovation and Development Joint Fund Key Support Project No.U23A20526Shanxi Province Science Foundation No.202203021221031
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common and highly aggressive tumor in the world. Although immunotherapy, surgical resection, targeted therapy and HCC transplantation could improve the prognosis for HCC patients, the tumor recurrence rate of the tumor remains high due to its insidious and invasive nature. Therefore, the development of new HCC therapeutic agents has become particularly important. Quinoa is abundant in bioactive peptides, proteins, and other functional ingredients that confer various health benefits to humans. Quinoa bran, the outer seed coat of quinoa, like quinoa, has extremely high nutritional value and rich protein content. This study firstly found that hydrolysate from quinoa bran protein (QBPP) exhibited targeting anti-HCC effect on the proliferation of HepG2 and Bel-7402 HCC cells in a concentration dependent manner, without significant toxic side effects on normal human liver cells L02. Further, QBPP exerted anti-HCC effect through mitochondria-mediated apoptosis and inhibition of HCC cells migration. Collectively, QBPP shows potential as a next-generation dietary supplement for the prevention and treatment of HCC.

Indexed as

ApoptosisCarcinoma, HepatocellularCell MovementCell ProliferationChenopodium quinoaLiver NeoplasmsPeptidesSeedsAntineoplastic Agents, PhytogenicCell Line, TumorHep G2 CellsHumansPlant ProteinsProtein HydrolysatesAntineoplastic Agents, PhytogenicPeptidesPlant ProteinsProtein HydrolysatesActive peptidesAnti-hepatocellular carcinomaCell apoptosisCell migrationQuinoa bran

Identifiers

PMID39757262

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.