Evidence map›Paper›PMID 39757351›Full record

ArticleAlcohol, clinical & experimental research2025

Impact of chronic ethanol consumption and SARS-COV-2 on the liver and intestine: A pilot dose-response study in mice.

Smita Ghare, Dennis Warner, Jeffrey Warner, Paula M Chilton, Jiyeon Lee, JingWen Zhang, Min Wang, Josiah Hardesty, Rui Treves, Jon Gabbard and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol, clinical & experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Smita GhareDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Dennis WarnerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Jeffrey WarnerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Paula M ChiltonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-8749-0975
Jiyeon LeeDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
JingWen ZhangDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Min WangDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Josiah HardestyDepartment of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Rui TrevesDepartment of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Jon GabbardCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Charles AndersonCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Lalit BatraCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Chithra SreenivasanCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Jennifer KraenzleCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Matthew McCulleyCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Stephanie McCoyCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Lihua ZhangDepartment of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Wenke FengDepartment of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Dibson Dibe GondimDepartment of Pathology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Shirish BarveDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.
Jian ZhengCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Kenneth PalmerCenter for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA.
Craig McClainDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-7219-8939
Irina KirpichAlcohol Research Center, University of Louisville, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0002-9545-6451

Funding

Project 4 - Smita Ghare, PhDP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · 2021 to 2025
$6.9M
The Role of Nutrition in the Development/Progression of Alcohol-Induced Organ InjuryP50AA024337 · NIAAA · UNIVERSITY OF LOUISVILLE · 2021 to 2025
$4.2M
Role of Soluble Epoxide Hydrolase in Alcohol-Associated Liver DiseaseR01AA028905 · UNIVERSITY OF LOUISVILLE · 2025 to 2025
$409k
Integrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical CenterU01AA026980 · UNIVERSITY OF LOUISVILLE · 2025 to 2025
$344k
BLRD VA I01 BX002996CSRD VA I01 CX002219NIAAA NIH HHS P50 AA024337NIAAA NIH HHS R01 AA028905NIAAA NIH HHS U01 AA026934NIAAA NIH HHS U01 AA026980NIGMS NIH HHS P20 GM113226NIH HHS 1U01AA026926-01NIH HHS 1U01AA026980-01NIH HHS P20GM113226NIH HHS P50AA024337NIH HHS R01AA028905NIH HHS U01AA026934U.S. Department of Veterans Affairs 1I01BX002996
6 · The paper itself

Abstract

backgroundDuring the coronavirus disease 2019 (COVID-19) pandemic, there was a marked increase in alcohol consumption. COVID-19 superimposed on underlying liver disease notably worsens the outcome of many forms of liver injury. The goal of a current pilot study was to test the dual exposure of alcohol and COVID-19 infection in an experimental animal model of alcohol-associated liver disease (ALD).

methodsAfter 4 weeks of ethanol (EtOH) feeding, C57BL/6 male mice received SARS-CoV-2 (SARS2-N501Y

resultsA similar gradual weight loss was observed in all inoculated mice (slightly less in the 3 × 10

conclusionsSARS-CoV-2 infection caused a dose-dependent negative impact on body weight and survival in mice fed EtOH. This pilot study suggests that early mortality observed after high-dose SARS-CoV-2 challenge could be due, in part, to hepatic dysfunction following chronic EtOH feeding.

Indexed as

Alcohol DrinkingCOVID-19EthanolIntestinesLiverLiver Diseases, AlcoholicSARS-CoV-2AnimalsDisease Models, AnimalDose-Response Relationship, DrugMaleMiceMice, Inbred C57BLPilot ProjectsEthanolalcohol‐associated liver diseaseanimal modelCOVID‐19

Identifiers

PMID39757351
PMCPMC11928281

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.