Evidence map›Paper›PMID 39757448›Full record

ArticleCNS spectrums2025

Beyond the hot flashes: how machine learning is uncovering the complexity of menopause-related depression.

Graziella Orrù, Rebecca Ciacchini, Anna Conversano, Ciro Conversano, Angelo Gemignani

Abstract read
In one paragraph

Article in CNS spectrums, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Graziella OrrùDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0002-8769-7693
Rebecca CiacchiniDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Anna ConversanoDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Ciro ConversanoDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Angelo GemignaniDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe transition into menopause marks a significant stage in a woman's life, indicating the end of reproductive capability. This period, encompassing perimenopause and menopause, is characterized by declining levels of estrogen and progesterone, leading to various symptoms such as hot flashes, sleep disturbances, sexual dysfunction, and mood irregularities. Moreover, cognitive functions, notably memory, may decline during this phase.

objectiveThis exploratory study aimed to evaluate psychological factors in a sample of 98 women recruited from a diagnostic-assistance hospital pathway (AOUP).

methodsPsychological variables, including depression, anxiety, stress, sleep quality, memory, personality traits, and mindfulness, were assessed using psychometric questionnaires. Machine learning techniques were employed to identify independent variables strongly correlated with higher levels of depression measured by BDI-II.

resultsThe findings revealed positive associations between depression and anxiety, stress, low mood, poor sleep quality, and memory complaints, while mindfulness showed a negative correlation. Remarkably, the machine learning analysis achieved a high classification accuracy in distinguishing between individuals with different levels of depression (low vs high).

conclusionsThese results underscore the importance of addressing psychological factors during menopause and offer valuable insights for future research and the development of targeted clinical interventions aimed at enhancing mental health and quality of life for women during this transitional phase.

Indexed as

DepressionHot FlashesMachine LearningMenopauseAdultAnxietyFemaleHumansMiddle Ageddepressionmachine learningmenopauseperimenopausepsychological assessment in menopausepsychology

Identifiers

PMID39757448
PMCPMC13064745

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.