Evidence map›Paper›PMID 39757642›Full record

ReviewCurrent cardiology reviews2025

Unlocking the Potential: Phytoestrogens and Cardiovascular Health.

Arvind Gulati, Himanshi Banker, Alina Amin Muhammad, Fnu Anamika, Rohit Jain

Abstract readReview
In one paragraph

Review in Current cardiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arvind GulatiDepartment of Internal Medicine, Maulana Azad Medical College, New Delhi, India.
Himanshi BankerDepartment of Internal Medicine, Maulana Azad Medical College, New Delhi, India.
Alina Amin MuhammadDepartment of Internal Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan.ORCID 0000-0002-7446-169X
Fnu AnamikaDepartment of Internal Medicine, University of Delhi, New Delhi, India.
Rohit JainDepartment of Internal Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytoestrogens are plant-derived compounds resembling human estrogen and have recently gained attention due to their potential role in improving cardiovascular health. These compounds exert their effects through various mechanisms, including interactions with estrogen receptors, growth factor receptors, inflammatory mediators, thrombogenic reactions, and apoptotic pathways. This results in cardioprotective effects like modulating endothelial function, decreasing vessel tone, reducing inflammation, altering lipid profiles, and influencing arrhythmogenesis. Recent studies indicate the intricate and multidimensional association between phytoestrogens and cardiovascular disease. Despite the overwhelming evidence that phytoestrogen intake lowers the risk of myocardial infarction (MI), prevents atherosclerosis, improves cardiac function, prevents hypertension, and reduces the risk of arrhythmias, there have been studies that show contradictory outcomes. For this reason, the therapeutic use of phytoestrogens for the treatment of cardiovascular diseases, which appears to be extremely promising, should be handled cautiously, considering the individual variances, dosage, and the specific components of phytoestrogens. This review consolidates findings on the effects of phytoestrogens on the heart and blood vessels, explores the mechanisms behind these interactions, and seeks to determine the best methods for using phytoestrogens as a supplement in managing and preventing cardiovascular disease. By understanding these aspects, we can better evaluate the potential of phytoestrogens in cardiovascular health and develop guidelines for their safe and effective use.

Indexed as

Cardiovascular DiseasesPhytoestrogensAnimalsHumansPhytoestrogensarrhythmias.cardiovascular diseasecongestive heart failuremyocardial infarction (MI)Phytoestrogensthrombogenic reactions

Identifiers

PMID39757642
PMCPMC12172217

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.