Evidence map›Paper›PMID 39758249›Full record

ArticleMolecular therapy. Oncology2024

Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade.

Mulu Z Tesfay, Yuguo Zhang, Khandoker U Ferdous, Mika A Taylor, Aleksandra Cios, Randal S Shelton, Camila C Simoes, Chelsae R Watters, Oumar Barro, Natalie M Elliott and 21 more

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Mulu Z TesfayDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Yuguo ZhangDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Khandoker U FerdousDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Mika A TaylorDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Aleksandra CiosDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Randal S SheltonDepartment of Pharmacology, UAMS, Little Rock, AR, USA.
Camila C SimoesDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Chelsae R WattersDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Oumar BarroDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Natalie M ElliottDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Bahaa MustafaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Jean Christopher ChamcheuSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, USA.
Alicia L GrahamDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Charity L WashamThe Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA.
Duah AlkamThe Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA.
Allen GiesThe Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA.
Stephanie D ByrumThe Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA.
Emmanouil GiorgakisCollege of Medicine, Surgery Transplant University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Steven R PostDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Thomas KellyDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.
Jun YingDepartment of Biostatistics, UAMS College of Public Health, Little Rock, AR, USA.
Omeed MoavenDivision of Surgical Oncology, Department of Surgery, Louisiana State University (LSU) Health, New Orleans, LA, USA.
Chiswili Y ChabuDivision of Biological Sciences, University of Missouri, Columbia, MO, USA.
Martin E Fernandez-ZapicoSchulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
Dan G DudaEdwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
Lewis R RobertsSchulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
Rang GovindarajanMedical Oncology Division, Internal Medicine Department, The University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Mitesh J BoradDepartment of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.
Martin J CannonThe Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA.
Alexei G BasnakianThe Winthrop P. Rockefeller Cancer Institute, UAMS, Little Rock, AR, USA.
Bolni M NagaloDepartment of Pathology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.

Funding

Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett · 2017 to 2026
$27.6M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Oncolytic Virotherapy in Hepatocellular CancerDP2CA195764 · NCI · MAYO CLINIC ARIZONA · PI BORAD, MITESH · 2014 to 2016
$2.7M
Novel Strategies to Enhance Drug Delivery and Tumor Immunogenicity in Pancreatic CancerDP2CA301099 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI NAGALO, BOLNI MARIUS · 2024 to 2024
$1.4M
Integrated molecular epidemiologic analysis of the one-carbon metabolism pathway and risk of HCCK01CA237875 · NCI · MAYO CLINIC JACKSONVILLE · PI ANTWI, SAMUEL O. · 2020 to 2024
$829k
cGAS-STING Pathway Targeting Replicative Adenoviruses with CD46 Tropism and AFP Promoter Conditional Replication Restriction for the Treatment of Hepatocellular CarcinomaK01CA234324 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI NAGALO, BOLNI MARIUS · 2018 to 2022
$667k
Harnessing the potential of pharmacological small molecules to amplify VSV-based oncolytic viral therapyR15CA290568 · NCI · SOUTHERN UNIV A&M COL BATON ROUGE · PI CHAMCHEU, JEAN CHRISTOPHER · 2024 to 2024
$409k
BLRD VA I01 BX002425BLRD VA IK6 BX006184NCI NIH HHS DP2 CA195764NCI NIH HHS DP2 CA301099NCI NIH HHS K01 CA234324NCI NIH HHS K01 CA237875NCI NIH HHS R15 CA290568NIGMS NIH HHS P20 GM121293NIGMS NIH HHS R24 GM137786
6 · The paper itself

Abstract

Members of the

Indexed as

hepatocellular carcinomaJurona virusoncolytic virusRhabdoviridaevesiculovirus

Identifiers

PMID39758249
PMCPMC11697550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.