ArticleFrontiers in neurology2024
Influences of different sedatives on gastric antrum contraction in patients with acute brain injury.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Biochemical impact of dexmedetomidine on inflammatory and stress markers in gastric cancer surgery: A meta-analysis.Journal of medical biochemistry · 2026Article
- Inhibitory Effect of Music Therapy Combined with Comfort Care on Reflux Events during Enteral Nutrition in Comatose Patients.Noise & healthArticle
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Authors and funding
9 authors.
Funding
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Abstract
Background: Patients with acute brain injury (ABI) often exhibit gastrointestinal motility disorder and the administration of sedatives may exacerbate the gastrointestinal dysfunction. This study aims to evaluate the influences of different sedatives on gastric antrum contraction in patients with acute brain injury (ABI). Methods: A prospective observational study was performed in 37 adult ICU patients with ABI, and 18 adult healthy volunteers were recruited as normal controls. Gastric motility, including frequency (ACF), amplitude (ACA), and motility index (MI), was measured with ultrasound before and after using sedatives, either propofol (Group A), midazolam (Group B), or dexmedetomidine (Group C). The influences of different sedatives on gastric motility were analyzed. Results: All patients with acute brain injury ( Conclusion: Patients with ABI exhibited decreased gastric motility. All sedatives, either propofol, midazolam, or dexmedetomidine, had inhibited effects on gastric motilities. Dexmedetomidine has less inhibitory effects on ACA and MI compared with propofol and midazolam.
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