ArticleHeliyon2024
Inflammation and oxidative stress processes in induced precocious puberty in rats.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- From nighttime light exposure to menstrual health: a critical review of evidence, mechanisms, and nursing interventions.Frontiers in reproductive health · 2026Review
- Article
- Research summary, possible mechanisms and perspectives of gut microbiota changes causing precocious puberty.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to assess the influence of different types of blue light sources on male and female rats' puberty onset, the morphologic-induced alterations in reproductive organs tissues, the impact on inflammation and oxidative stress markers, anxiety levels, and mathematical modeling for tissue data interpretation. Four groups of sixteen rats each (8 females and 8 males/group) were investigated: three groups were exposed to blue light from mobile phones (MP), computer screens (PC), or LED lamps (LED) versus the control group (CTRL). The rats in the CTRL group had no exposure while the other groups were exposed for 30 days to the blue light of MP, PC, and LED for 16 h per day. Serum levels of cortisol, TNF-α, IL-6, and MMP-2 and MMP-9 ovaries and testis tissue levels were analyzed using the ELISA technique. Total oxidative stress (TOS), nitric oxide (NO), and malondialdehyde (MDA) in serum were determined spectrophotometrically. Histomorphological examination was performed on both male and female genital organs. Rats of both sexes presented significant early onset of puberty secondary to blue light exposure. LED-emitted light significantly increased TNF-α and MMP-9 levels in both sexes. The MP and PC emitted light significantly affected the levels of MMP-2 in both females and males. Levels of TOS and NO were increased by LED, respectively by MP and LED exposure in female rats. The histopathological examination revealed no statistically significant differences in the ovaries and testes of rats across the different groups. Blue light exposure induces precocious puberty, by accelerating sexual maturation, and triggers the overproduction of MMPs that could promote organic alteration through tissue remodeling. Oxidative stress parameters were upregulated only in female rats, while cortisol levels were higher in male rats.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.