Evidence map›Paper›PMID 39760130›Full record

ArticleInternational journal of cardiology. Cardiovascular risk and prevention2025

Causal associations between hypertension and abnormal brain cortical structures: Insights from a bidirectional Mendelian randomization study.

Tianxiang Fang, Xizhi Wang, Yingsong Wang, Xiaoya Zheng, Ning Huangfu

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In one paragraph

Article in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tianxiang FangDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Xizhi WangDepartment of Cardiology, Lihuili Hospital Affiliated to Ningbo University, Ningbo, China.
Yingsong WangDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Xiaoya ZhengHealth Science Center, Ningbo University, Ningbo, China.
Ning HuangfuDepartment of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Observational studies suggest that hypertension affects brain cortical structure. However, the potential causal association has yet to be entirely determined. Thus, we aim to assess the causality between hypertension and abnormal cortical structure. Methods: We conducted a bidirectional Mendelian randomization (MR) study to estimate their relationship. Genome-wide association study summary statistics of hypertension (n = 484,598) and brain cortical (surface area and thickness) (n = 51,665) were derived from publicly available databases. Sensitivity analyses were applied to ensure the robustness of the results. Results: The study showed that hypertension was associated with a decline in total brain cortical thickness [β, -0.0308 mm; 95 % confidence interval (CI), -0.0610 to -0.0007; Conclusion: Our study showed causal relationships between hypertension and changes in specific brain cortical, providing new evidence for the heart-brain axis theory.

Indexed as

Brain corticalCaudal anterior cingulate cortexHeart-brain axisHypertensionInsulaMendelian randomization

Identifiers

PMID39760130
PMCPMC11696852

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.