ArticleeLife2025
Plural molecular and cellular mechanisms of pore domain
Abstract readCase Reports
In one paragraph
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Assessment of gabapentin efficacy in patients with KCNQ2-developmental epileptic encephalopathy.Scientific reports · 2026Article
- Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Novel proteolytic post-translational modification in voltage-gated potassium channel KCNQ2.Scientific reports · 2026Article
- Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Molecular dynamics of the pathogenic KCNQ2 variant G256W reveal mechanisms of channel dysfunction in epileptic encephalopathy.bioRxiv : the preprint server for biology · 2025Article
- Human iPSC-derived glutamatergic neurons with pathogenic KCNQ2 variants display hyperactive bursting phenotypes.Neurobiology of disease · 2025Article
- Special Issue "Ion Conductance and Ion Regulation in Human Health and Disease".International journal of molecular sciences · 2025Article
Corrections and comments
- Update of
Authors and funding
25 authors.
Timothy J AbreoDepartment of Neurology, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0001-5675-7932
Emma C Thompson *Department of Neurology, Baylor College of Medicine, Houston, United States.
Anuraag Madabushi *Department of Neurology, Baylor College of Medicine, Houston, United States.
Kristen L Park *Department of Neurology, Children's Colorado, University of Colorado, Aurora, United States.ORCID https://orcid.org/0000-0001-5527-3047
Heun SohDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Nissi VargheseDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Carlos G VanoyeDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, United States.ORCID https://orcid.org/0000-0002-4935-1122
Kristen SpringerDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Jim JohnsonKCNQ2 Cure Alliance, Denver, United States.
Scotty SimsKCNQ2 Cure Alliance, Denver, United States.
Zhigang JiDepartment of Neurology, Baylor College of Medicine, Houston, United States.
Ana G ChavezDepartment of Neurology, Baylor College of Medicine, Houston, United States.
Miranda J JankovicDepartment of Neurology, Baylor College of Medicine, Houston, United States.
Bereket HabteDepartment of Neurology, Children's Colorado, University of Colorado, Aurora, United States.
Aamir R ZuberiThe Rare Disease Translational Center & Technology Evaluation and Development, The Jackson Laboratory, Bar Harbor, United States.ORCID https://orcid.org/0000-0003-0252-9760
Cathleen M LutzThe Rare Disease Translational Center & Technology Evaluation and Development, The Jackson Laboratory, Bar Harbor, United States.
Zhao WangDepartment of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, United States.
Vaishnav KrishnanDepartment of Neurology, Baylor College of Medicine, Houston, United States.
Lisa DudlerCenter for Human Genetics Tübingen, Tübingen, Germany.
Stephanie Einsele-ScholzCenter for Human Genetics Tübingen, Tübingen, Germany.
Jeffrey L NoebelsDepartment of Neurology, Baylor College of Medicine, Houston, United States.
Alfred L GeorgeDepartment of Neurology, Children's Colorado, University of Colorado, Aurora, United States.ORCID https://orcid.org/0000-0002-3993-966X
Atul MaheshwariDepartment of Neurology, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0003-3045-7901
Anastasios TzingounisDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, United States.
Edward C CooperDepartment of Neurology, Baylor College of Medicine, Houston, United States.ORCID https://orcid.org/0000-0003-3672-8442
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MShared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9MThe Jackson Laboratory Center for Precision GeneticsU54OD030187 · OD · JACKSON LABORATORY · PI Cathleen M Lutz · 2020 to 2026
$17.2MProject 3 - Development and investigation of murine models of channelopathy-associated epilepsyU54NS108874 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2018 to 2022
$12.1MThe Jackson Laboratory Center for Precision Genetics: From New Models to Novel TherapeuticsU54OD020351 · OD · JACKSON LABORATORY · PI NISHINA, PATSY M · 2015 to 2019
$10.2MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MPLASTICITY IN DEVELOPING EPILEPTIC BRAINR01NS029709 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI NOEBELS, JEFFREY · 1991 to 2025
$9.1MRole of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1MMechanisms of benign neonatal familial convulsionsR01NS049119 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI COOPER, EDWARD C · 2005 to 2017
$3.8MMolecular Assembly of Bacterial Tripartite Multidrug Efflux PumpsR01AI179879 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Zhao Wang · 2024 to 2026
$1.9MKCNQ2/3 channels and interneuron physiologyR01NS101596 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI TZINGOUNIS, ANASTASIOS · 2017 to 2021
$1.7MMolecular mechanism of Androgen Receptor mediated transcriptionR01GM143380 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI WANG, ZHAO · 2021 to 2025
$1.7MAmerican Epilepsy Society Predoctoral FellowshipCancer Prevention and Research Institute of Texas RP190602Citizens United for Research in Epilepsy Pediatric Epilepsy AwardNCI NIH HHS P30 CA034196NCI NIH HHS P30 CA125123NHLBI NIH HHS R01 HL137094NHLBI NIH HHS R01 HL162842NIAID NIH HHS R01 AI179879NICHD NIH HHS P50 HD103555NIGMS NIH HHS R01 GM143380NIH HHS S10 OD026804NIH HHS U54 OD020351NIH HHS U54 OD030187NIMH NIH HHS MH126953NIMH NIH HHS R56 MH126953NINDS NIH HHS K08 NS096029NINDS NIH HHS K08 NS110924NINDS NIH HHS R01 NS029709NINDS NIH HHS R01 NS049119NINDS NIH HHS R01 NS101596NINDS NIH HHS R01 NS108874NINDS NIH HHS R01 NS29709NINDS NIH HHS R01 NS49119NINDS NIH HHS U54 NS108874NINDS NIH HHS U54 OD020351Welch Foundation Q-2173-20230405
Abstract
PubMed holds no abstract for this paper.
Indexed as
KCNQ2 Potassium ChannelAnimalsBrain DiseasesCarbamatesCryoelectron MicroscopyDisease Models, AnimalEpilepsyFemaleHumansMaleMiceNerve Tissue ProteinsPhenylenediaminesPyramidal CellsCarbamatesezogabineKCNQ2 Potassium ChannelKCNQ2 protein, humanKcnq2 protein, mouseNerve Tissue ProteinsPhenylenediaminesaxon initial segmentbrain developmentchannelopathyepilepsygeneticsgenomicshumanmouseneuroscienceprecision medicine
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.