Evidence map›Paper›PMID 39761424›Full record

ArticleGut microbes2025

Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.

Baohua Luo, Qingling An, Jingyu Lei, Dengxu Tan, Xiaoqiu Liu, Hui Li, Yong Zhao, Jing Qin, Caiqin Zhang, Yongbin Zhang and 1 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Aging and cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Baohua LuoDivision of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Qingling AnDivision of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Jingyu LeiSchool of Basic Medicine, Medical College of Yan'an University, Yan'an, P.R. China.
Dengxu TanDivision of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Xiaoqiu LiuScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China.
Hui LiSchool of Basic Medicine, Medical College of Yan'an University, Yan'an, P.R. China.
Yong ZhaoDivision of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Jing QinDivision of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Caiqin ZhangDivision of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Yongbin ZhangLaboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China.
Changhong ShiDivision of Cancer Biology, Laboratory Animal Center, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.ORCID 0000-0001-7490-3593

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

significanceThe anti-PD-1 mAb may be further considered along with PGD2 or active molecules that can promote PGD2 synthesis to enhance the anti-tumor immune response.

Indexed as

Gastrointestinal MicrobiomeProgrammed Cell Death 1 ReceptorProstaglandin D2ResveratrolAnimalsCell Line, TumorHumansMiceProgrammed Cell Death 1 ReceptorProstaglandin D2Resveratrolimmune checkpoint inhibitorsintestinal microbiotapancreatic cancerprostaglandin D2Resveratrol

Identifiers

PMID39761424
PMCPMC12931716

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.