Evidence map›Paper›PMID 39761900›Full record

ArticleInternational journal of biological macromolecules2025

Computational insights into the aggregation mechanism of human calcitonin.

Fengjuan Huang, Xinjie Fan, Huan Xu, Zhongyue Lv, Yu Zou, Jiangfang Lian, Feng Ding, Yunxiang Sun

Abstract read
In one paragraph

Article in International journal of biological macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Molecular-level understanding of the aging bone and regeneration mechanisms using computational methods.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  2. Article
  3. The Glycine-Rich Region as a Flexible Molecular Glue Promoting hPrPJournal of chemical information and modeling · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fengjuan HuangNingbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo 315211, China.
Xinjie FanSchool of Physical Science and Technology, Ningbo University, Ningbo 315211, China.
Huan XuSchool of Physical Science and Technology, Ningbo University, Ningbo 315211, China.
Zhongyue LvDepartment of Neurology, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315040, China.
Yu ZouDepartment of Sport and Exercise Science, Zhejiang University, Hangzhou 310058, China.
Jiangfang LianNingbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo 315211, China. Electronic address: hjmpin@163.com.
Feng DingDepartment of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States. Electronic address: fding@clemson.edu.
Yunxiang SunSchool of Physical Science and Technology, Ningbo University, Ningbo 315211, China; Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, United States. Electronic address: sunyunxiang@nbu.edu.cn.

Funding

Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Jeryl Jones · 2018 to 2026
$24.7M
Inhibition of Human Islet Amyloid Polypeptide AggregationR35GM145409 · NIGMS · CLEMSON UNIVERSITY · PI Feng Ding · 2022 to 2026
$2.0M
NIGMS NIH HHS P20 GM121342NIGMS NIH HHS R35 GM145409
6 · The paper itself

Abstract

Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its abnormal aggregation can disrupt physiological functions and increase the risk of medullary thyroid carcinoma. To elucidate the mechanisms underlying hCT aggregation, we investigated the self-assembly dynamics of hCT segments (hCT

Indexed as

CalcitoninMolecular Dynamics SimulationProtein AggregatesAmino Acid SequenceHumansProtein Conformation, beta-StrandProtein MultimerizationProtein Structure, SecondaryCalcitoninProtein AggregatesAmyloid aggregationDiscrete molecular dynamicsHuman calcitonin

Identifiers

PMID39761900
PMCPMC12459280

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.