Evidence map›Paper›PMID 39762216›Full record

ArticleGut microbes2025

Divergence of gut bacteria through the selection of genomic variants implicated in the metabolism of sugars, amino acids, and purines by small extracellular vesicles in milk.

Fang Zhou, Peerzada Tajamul Mumtaz, Haluk Dogan, Roland Madadjim, Juan Cui, Janos Zempleni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Milk-Derived Extracellular Vesicles and microRNAs: Potential Modulators of Intestinal Homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fang ZhouDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
Peerzada Tajamul MumtazDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.
Haluk DoganSchool of Computing, University of Nebraska-Lincoln, Lincoln, NE, USA.
Roland MadadjimSchool of Computing, University of Nebraska-Lincoln, Lincoln, NE, USA.
Juan CuiSchool of Computing, University of Nebraska-Lincoln, Lincoln, NE, USA.
Janos ZempleniDepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA.

Funding

The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
Nebraska Center for the Prevention of Obesity Diseases through Dietary MoleculesP30GM154608 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI JANOS ZEMPLENI · 2024 to 2026
$4.7M
Bioengineering of Customized Exosomes as a Cell-free Therapy for Volumetric Muscle Loss Injuries ProposalR03EB036096 · NIBIB · CLEVELAND STATE UNIVERSITY · PI SIKDER, PRABAHA · 2024 to 2025
$149k
National Institute of Food and Agriculture 2016-67001-25301NIBIB NIH HHS R03 EB036096NIGMS NIH HHS P20 GM104320NIGMS NIH HHS P30 GM154608
6 · The paper itself

Abstract

Here, we report that small extracellular vesicles (sEVs) in milk mediate the communication between bacteria and animal kingdoms, increase the divergence of bacteria in the intestine, and alter metabolite production by bacteria. We show that bovine milk sEVs select approximately 55,000 genomic variants in 19 species of bacteria from the murine cecum

Indexed as

Amino AcidsBacteriaExtracellular VesiclesGastrointestinal MicrobiomeMilkPurinesAnimalsCattleCecumGenetic VariationHumansMiceMice, Inbred C57BLMilk, HumanSugarsAmino AcidsPurinesSugarsBacteriaexosomesextracellular vesiclesgenomic variantsmilk

Identifiers

PMID39762216
PMCPMC12716043

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.