Evidence map›Paper›PMID 39762377›Full record

ArticleScientific reports2025

A mouse model of deep vein thrombosis by inferior vena cava hypoperfusion using ameroid constrictors.

Hiroko Tadokoro, Yukihide Ota, Mari Uomoto, Shiro Koizume, Shinya Sato, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Yoko Endo-Takahashi, Yoichi Negishi, Etsuko Miyagi and 1 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hiroko TadokoroMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Yukihide OtaMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Mari UomotoMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Shiro KoizumeMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Shinya SatoMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Yoshiyasu NakamuraMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Mitsuyo YoshiharaMorphological Information Analysis Laboratory, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa, 241‑8515, Japan.
Yoko Endo-TakahashiDepartment of Drug Delivery and Molecular Biopharmaceutics, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, 192-0392, Tokyo, Japan.
Yoichi NegishiDepartment of Drug Delivery and Molecular Biopharmaceutics, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, 192-0392, Tokyo, Japan.
Etsuko MiyagiDepartment of Obstetrics and Gynecology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Kanagawa, Japan.
Yohei MiyagiMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan. miyagi.0e82r@kanagawa-pho.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional mouse models for deep vein thrombosis (DVT), frequently utilized in research focused on cancer-associated thrombosis (CAT), reliably induce thrombus formation by obstructing blood flow (BF) in the inferior vena cava (IVC), which does not occur in humans. Therefore, to develop a new DVT model for CAT studies, we implanted an ameroid constrictor (AC), a hygroscopic casein C-shape device, around the IVC and aorta of immunocompromised mice. We evaluated the thrombus 3 and 8 days post-AC implantation and compared it with the traditional model 2 days post-vena cava ligation. The size of each thrombus was measured, and the composition was assessed using histological staining; BF through the IVC was confirmed using ultrasound imaging. The thrombus size variability in the AC and ligation models was equivalent. Compared with thrombi on day 3 post-AC implantation, those on day 8 showed characteristics of human thrombi in the subacute to chronic stage. The BF in the IVC was maintained even on day 8. In summary, the AC model showed reproducibility with no significant difference in thrombus size variability from the traditional ligation model while maintaining the BF of the IVC.

Indexed as

Disease Models, AnimalVena Cava, InferiorVenous ThrombosisAnimalsHumansMaleMiceAnimal modelBlood flowCancer-associated thrombosisNude miceUltrasound imageVenous thrombosis

Identifiers

PMID39762377
PMCPMC11704261

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.