Evidence map›Paper›PMID 39762964›Full record

ArticleDiabetology & metabolic syndrome2025

Pre-pregnancy BMI modifies the associations between triglyceride-glucose index in early pregnancy and adverse perinatal outcomes: a 5-year cohort study of 67,936 women in China.

Li Li, Yulai Zhou, Huan Li, Juan Li, Lishi Huang, Weibin Wu

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In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li Li *The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910, Hengshan Rd., Shanghai, 200030, China.
Yulai Zhou *The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910, Hengshan Rd., Shanghai, 200030, China.
Huan Li *Songjiang Maternity and Child Health Hospital, Shanghai, 200030, China.
Juan LiThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910, Hengshan Rd., Shanghai, 200030, China.
Lishi HuangThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910, Hengshan Rd., Shanghai, 200030, China. 17802163577@163.com.
Weibin WuThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, No. 910, Hengshan Rd., Shanghai, 200030, China. wuweibin01@gmail.com.ORCID http://orcid.org/0000-0003-3637-754X

Funding

National Natural Science Foundation of China 82271706Programs for Science and Technology Development of Songjiang District, Shanghai 2024SJKJGG094
6 · The paper itself

Abstract

backgroundTriglyceride-glucose (TyG) index was suggested as a possible surrogate for insulin resistance and a predictor for cardiovascular diseases and diabetes in the non-pregnant population. However, the relationship between TyG index in early pregnancy and adverse pregnancy outcomes (APOs), and the contribution of pre-pregnancy body mass index (BMI) was still illusive.

methodsA large retrospective cohort study involving 67,936 pregnant Chinese women between 2017 and 2022 was conducted. Data collection and laboratory tests were performed during the usual patient care. TyG index was calculated using ln [fasting plasma triglyceride (TG; mmol/L) × 88.5 × glucose (FPG; mmol/L) × 18.02/2]. Multivariable logistic regression models were applied to explore the relationship between TyG index and APOs. Interaction and stratification analyses were performed to assess the influence of pre-pregnancy BMI on the association. In addition, ROC curves were used to evaluate the potential predictive value of the TyG index and pre-pregnancy BMI.

resultsPositive associations between maternal early pregnancy TyG index and APOs, including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), large for gestational age (LGA) and preterm birth (PTB) were demonstrated (all P < 0.001). Besides, there was a significant interaction effect of maternal pre-pregnancy BMI and TyG on the risk of GDM, HDP and LGA (P < 0.05). Women of pre-pregnancy overweight/obesity (OWO) with TyG index in the fourth quartile were at an increased risk for GDM [adjusted OR (aOR) and 95% CI, 3.82 (3.14-4.64)], HDP [aOR 95% CI, 1.34 (1.10-1.64)], for LGA [aOR 95% CI, 1.78 (1.44-2.19)], and PTB [aOR 95% CI, 1.53 (1.11-2.09)], compared with OWO mothers with TyG in the lowest quartile. In addition, the combination of BMI and TyG enhanced predictive performance for APOs, particularly in women with normal plasma TG and FPG levels.

conclusionsDose-response relationships were identified between elevated maternal TyG index in early pregnancy and APOs. A combination of early pregnancy TyG index and pre-pregnancy BMI may provide predictive value for APOs, even in low-risk women. Thus, early screening of fasting blood lipids and glucose simultaneously may be useful and convenient for the early identification of APOs, both among OWO and low-risk normal-weight women.

Indexed as

Gestational diabetes mellitusHypertensive disorders of pregnancyLarge for gestational agePre-pregnancy BMIPreterm birthTriglyceride-glucose index

Identifiers

PMID39762964
PMCPMC11702117

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.