ArticleDiabetes, obesity & metabolism2025
Association between the changes in the estimated glucose disposal rate and new-onset cardiovascular disease in middle-aged and elderly individuals: A nationwide prospective cohort study in China.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Impact of a 12-week personalized dietary intervention on vascular function and cardiovascular risk factors.Diabetes, obesity & metabolism · 2025Trial
- Association of an estimated glucose disposal rate-frailty index with incident cardiovascular events in two prospective cohorts.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Association between eGDR and the risk of chest pain: A comparative analysis based on NHANES and CHARLS databases.Medicine · 2026Article
- Differential associations between novel triglyceride-glucose-obesity indices and incident stroke in individuals with early-stage cardiovascular-kidney-metabolic syndrome: a longitudinal cohort study.Cardiovascular diabetology · 2026Article
- Associations of long-term average and variability of estimated glucose disposal rate with frailty progression: evidence from two prospective cohorts.Journal of translational medicine · 2026Article
- Comparative prognostic value of TyG index and TyG-BMI for 90-day all-cause mortality in critically ill older adults with ASCVD: a machine learning analysis of the MIMIC-IV database.Cardiovascular diabetology · 2026Article
- Changes in the estimated glucose disposal rate and cardiometabolic multimorbidity in middle-aged and older adults.Cardiovascular diabetology · 2026Article
- Article
- Association of cumulative obesity- and insulin resistance-related indices with incident cardiovascular disease in Chinese middle-aged and elderly populations: a nationwide prospective cohort study.Journal of health, population, and nutrition · 2026Article
- Serum high-density lipoprotein partially mediates the inverted L-shaped association between estimated glucose disposal rate and risk of kidney stones: A cross-sectional study from National Health and Nutrition Examination Survey.The Journal of international medical research · 2026Article
- Association of dietary acid load with diabetes and glucose metabolism index in Chinese adults: a cross-sectional study.Food & nutrition research · 2026Article
- Association between triglyceride-glucose index-a body shape index and atherosclerotic cardiovascular disease, and the modification effect of dietary patterns.Frontiers in nutrition · 2026Article
- Joint association of urinary albumin-to-creatinine ratio within normal range and triglyceride-glucose index with incident cardiovascular disease: a prospective cohort study.Cardiovascular diabetology · 2025Article
- Association between changes in estimated glucose disposal rate and composite kidney outcome in middle-aged and elderly individuals: a national cohort study.Diabetology & metabolic syndrome · 2025Article
- Changes in the estimated glucose disposal rate and incident cardiovascular disease in patients with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study in China.BMC cardiovascular disorders · 2025Article
- Longitudinal changes in estimated glucose disposal rate and risk of cardiovascular disease among adults with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.European journal of medical research · 2025Article
- Associations of Estimated Glucose Disposal Rate With Stroke Risk and Poststroke Adverse Outcomes: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2025Article
- Estimated glucose disposal rate outperforms other insulin resistance surrogates in predicting incident cardiovascular diseases in cardiovascular-kidney-metabolic syndrome stages 0-3 and the development of a machine learning prediction model: a nationwide prospective cohort study.Cardiovascular diabetology · 2025Article
- Association between the changes in the estimated glucose disposal rate and new-onset cardiovascular disease in middle-aged and elderly individuals: A nationwide prospective cohort study in China.Diabetes, obesity & metabolism · 2025Article
- Association of platelet-to-high-density lipoprotein cholesterol ratio and its cumulative exposure with cardiovascular disease risk: a prospective cohort study in Chinese population.Frontiers in cardiovascular medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
aimsPrevious studies have shown that eGDR and TyG, as indicators of insulin resistance (IR), were key risk factors for cardiovascular disease (CVD). Our study further explored the relationship between eGDR change and new-onset CVD, and compared the predictive value of eGDR change, eGDR and TyG. MATERIALS AND
methodsA total of 2895 participants without CVD at baseline from the China Health and Retirement Longitudinal Study (CHARLS) were included, using K-means clustering and cumulative eGDR to measure eGDR change between 2012 and 2015. Cox and restricted cubic splines (RCS) regression models assessed the relationship between eGDR change and new-onset CVD. The predictive value of TyG, eGDR and eGDR change for outcomes was evaluated using receiver operating characteristic (ROC) curves, net reclassification improvement (NRI) and integrated discrimination improvement (IDI).
resultsDuring a mean follow-up of 4.42 years, 581 CVD cases occurred, including 389 heart disease cases and 249 stroke cases. Participants with consistently low eGDR had a higher new-onset CVD risk (HR: 2.51, 95%CI: 2.04-3.09). A stepwise increase of outcomes was observed with the increased cumulative eGDR (p for trend <0.001). Further analysis showed the correlation between cumulative eGDR and outcomes was linear. Compared to eGDR and TyG, cumulative eGDR exerted greater predictive effect as evaluated by area under curve, IDI and NRI.
conclusionsSustained low eGDR was related to an increased risk of new-onset CVD in middle-aged and elderly population. Continuous monitoring of eGDR significantly enhances the accuracy of new-onset CVD risk stratification, which may reduce the incidence of new-onset CVD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.