ArticleNeurogastroenterology and motility2025
Small Intestinal Slow Wave Dysrhythmia and Blunted Postprandial Responses in Diabetic Rats.
Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Progressive impairment in gastric and duodenal slow waves and autonomic function during progression of type 2 diabetes in rats.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundGastric dysmotility and gastric slow wave dysrhythmias have been well documented in patients with diabetes. However, little is known on the effect of hyperglycemia on small intestine motility, such as intestinal slow waves, due to limited options in measuring its activity. Moreover, food intake and digestion process have been reported to alter the small intestine motility in normal rats, but their roles in that of diabetic rats remains unknown. This study aimed to explore the effect of hyperglycemia on small intestinal myoelectrical activity (IMA) and responses to various meals in diabetic and normal rats.
methodsIMA was recorded via chronically implanted serosal electrodes in the proximal small intestine in rats with type 2 diabetes induced by high-fat diet feeding followed by a low dose of streptozotocin (30 mg/kg) and normal rats. The percentage of normal slow wave (%NSW), dominant power, and dominant frequency (DF) were assessed from the IMA under various conditions. Oral glucose tolerance test was performed, and blood was collected via the tail vein at baseline and 15, 30, 60, 90, 120, and 180 min after glucose administration for the measurement of blood glucose. Regular laboratory chow, high-fat diet, and small or large nutrient liquid meal were used to explore IMA responses to different meals in diabetic and normal rats.
results(1) Compared with a postprandial increase in DF in normal rats (p = 0.007), diabetic rats showed a blunted postprandial response in DF (p = 0.145) after a regular chow. However, no difference was found in %NSW between diabetic and normal rats in both fasting and fed states; (2) In the fasting state, %NSW was correlated with the blood glucose level in diabetic rats (r = -0.817, p = 0.004, N = 8) as well as HbA1C (r = -0.871, p = 0.005, N = 8). After glucose administration, the increase in blood glucose was correlated with a decrease in %NSW (r = -0.655, p < 0.001, N = 8). (3) %NSW in diabetic rats during the 30-min postprandial state was not altered after a meal, either liquid or solid, regular or high-fat diet, small or large meal, suggesting an absence of gastric-small intestinal reflex.
conclusionsIn type 2 diabetic rats, the regularity of intestinal slow waves is negatively correlated with the blood glucose level in both fasting and fed states. Diabetic rats exhibit a blunted postprandial response in intestinal slow waves compared with normal rats. There seems to be a lack of gastric-small intestinal reflex upon food ingestion in diabetic rats.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.