Evidence map›Paper›PMID 39763366›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2026

Genetics of intracerebral hemorrhage.

Tamara N Kimball, Reinier Wp Tack, Anna Chen, Savvina Prapiadou, Jasper R Senff, Benjamin Yq Tan, Sanjula D Singh, Susanne J van Veluw, Steven M Greenberg, Jonathan Rosand and 1 more

Abstract readReview
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tamara N KimballMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Reinier Wp TackMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Anna ChenMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Savvina PrapiadouMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Jasper R SenffMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Benjamin Yq TanMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Sanjula D SinghMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Susanne J van VeluwDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-7957-8643
Steven M GreenbergDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Jonathan RosandMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
Christopher D AndersonMcCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-0053-2002

Funding

Sequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4M
Training Program in Recovery and Restoration of CNS health and functionT32NS100663 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LEIGH R HOCHBERG, JONATHAN ROSAND · 2017 to 2026
$2.5M
NINDS NIH HHS R01 NS103924NINDS NIH HHS T32 NS100663
6 · The paper itself

Abstract

Spontaneous intracerebral hemorrhage(ICH) represents a life-threatening form of stroke, marked by its impact on survival and quality of life. ICH can be categorized from monogenic disorders linked to causal germline variants in ICH-related genes to complex sporadic cases, highlighting the interaction among lifestyle factors, environmental influences, and genetic components in determining risk. Among sporadic ICH, the influence of these factors varies across ICH subtypes, evidenced by heritability rates of up to 73% for lobar ICH versus 34% for non-lobar ICH. This review presents an outline of the genetic landscape of ICH, covering both monogenic and sporadic forms. It highlights associations between ICH risk and genetic variants, including rare and common variants in genes such as

Indexed as

Cerebral HemorrhageGenetic Predisposition to DiseaseHumansRisk FactorsCerebral amyloid angiopathyGWASintracerebral hemorrhagemonogenic disorderssporadic ICH

Identifiers

PMID39763366
PMCPMC13579123

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.