Evidence map›Paper›PMID 39763516›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Acute Myeloid Leukemia Skews Therapeutic WT1-specific CD8 TCR-T Cells Towards an NK-like Phenotype that Compromises Function and Persistence.

Francesco Mazziotta, Lauren E Martin, Daniel N Eagan, Merav Bar, Sinéad Kinsella, Kelly G Paulson, Valentin Voillet, Miranda C Lahman, Daniel Hunter, Thomas M Schmitt and 14 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Francesco MazziottaProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Lauren E MartinProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Daniel N EaganTranslational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Merav BarTranslational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sinéad KinsellaProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Kelly G PaulsonTranslational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Valentin VoilletVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Miranda C LahmanProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Daniel HunterProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Thomas M SchmittProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Natalie DuerkoppProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cecilia YeungTranslational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Tzu-Hao TangProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Raphael GottardoBiomedical Data Science Center, Lausanne University Hospital.
Yuta AsanoProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Elise C WilcoxProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Bo LeeProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Tianzi ZhangProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Paolo LopedoteDepartment of Medicine, St. Elizabeth's Medical Center, Boston University, Boston, MA, USA.
Livius PenterDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Catherine J WuDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Filippo MilanoTranslational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Philip D GreenbergProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Aude G ChapuisProgram in Immunology, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STEPHANIE J LEE · 1985 to 2026
$128.4M
Interdisciplinary Tranining in Cancer ResearchT32CA080416 · NCI · UNIVERSITY OF WASHINGTON · PI STODDARD, BARRY L. · 1998 to 2023
$9.7M
Targeting Leukemia with Memory CD8+ T cells Transduced to Express High-Affinity WK08CA169485 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI CHAPUIS, AUDE · 2013 to 2017
$857k
NCI NIH HHS K08 CA169485NCI NIH HHS P01 CA018029NCI NIH HHS T32 CA080416
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) that is relapsed and/or refractory post-allogeneic hematopoietic cell transplantation (HCT) is usually fatal. In a prior study, we demonstrated that AML relapse in high-risk patients was prevented by post-HCT immunotherapy with Epstein-Barr virus (EBV)-specific donor CD8

Identifiers

PMID39763516
PMCPMC11702715

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.