Evidence map›Paper›PMID 39763558›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Community Threat, Positive Parenting, and Accelerated Epigenetic Aging: Longitudinal Links from Childhood to Adolescence.

Georgette Metrailer, Karina Tavares, Mikayla Ver Pault, Adamari Lopez, Shane Denherder, Evelyn Hernandez Valencia, Karissa DiMarzio, April Highlander, Sarah M Merrill, Darlynn M Rojo-Wissar and 1 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Georgette MetrailerAlpert Medical School of Brown University, Providence, RI.ORCID 0009-0009-7795-4156
Karina TavaresUniversity of Rhode Island, Kingston, RI.ORCID 0009-0003-4262-1569
Mikayla Ver PaultUniversity of Rhode Island, Kingston, RI.
Adamari LopezUniversity of Rhode Island, Kingston, RI.
Shane DenherderUniversity of Rhode Island, Kingston, RI.
Evelyn Hernandez ValenciaUniversity of Rhode Island, Kingston, RI.ORCID 0009-0009-0207-3522
Karissa DiMarzioFlorida International University, Miami, FL.ORCID 0000-0002-5626-8351
April HighlanderAlpert Medical School of Brown University, Providence, RI.ORCID 0000-0002-4844-1548
Sarah M MerrillUniversity of Massachusetts, Lowell, MA.ORCID 0000-0002-6939-5472
Darlynn M Rojo-WissarAlpert Medical School of Brown University, Providence, RI.ORCID 0000-0001-7353-1353
Justin ParentUniversity of Rhode Island, Kingston, RI.ORCID 0000-0002-1659-8188

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
Fragile Families and the Transition to AdulthoodR01HD036916 · NICHD · PRINCETON UNIVERSITY · PI Kathryn Edin, Jane Waldfogel · 1999 to 2026
$46.3M
Project 3: Isolating food insecurity to understand childhood health outcomes and biological mechanisms of riskP20GM139767 · NIGMS · MIRIAM HOSPITAL · PI KayLoni L. Olson · 2021 to 2026
$14.6M
ECONOMIC STATUS, PUBLIC POLICY, AND CHILD NEGLECTR01HD039135 · NICHD · PRINCETON UNIVERSITY · PI PAXSON, CHRISTINA H · 2000 to 2004
$3.1M
Child Care and Parental Employment in Fragile FamiliesR01HD040421 · NICHD · COLUMBIA UNIVERSITY TEACHERS COLLEGE · PI BROOKS-GUNN, JEANNE · 2002 to 2006
$2.8M
Epigenomic mechanisms of risk and resilience: The role of parentingR01MD015401 · NIMHD · UNIVERSITY OF RHODE ISLAND · PI PARENT, JUSTIN · 2020 to 2024
$2.0M
Research Training in Childhood Stress, Trauma, and ResilienceT32HD101392 · NICHD · MIRIAM HOSPITAL · PI PARADE, STEPHANIE HART, STROUD, LAURA R · 2020 to 2024
$1.7M
Development and implementation of a digital sleep intervention for preschoolers in foster careK01HL169495 · NHLBI · EMMA PENDLETON BRADLEY HOSPITAL · PI ROJO-WISSAR, DARLYNN MARIE · 2023 to 2024
$350k
A dimensional approach to understanding emotional neglect and its impact on children's psychosocial development: A mixed methods studyF31HD106768 · NICHD · FLORIDA INTERNATIONAL UNIVERSITY · PI DIMARZIO, KARISSA A · 2021 to 2022
$74k
NHLBI NIH HHS K01 HL169495NICHD NIH HHS F31 HD106768NICHD NIH HHS L40 HD103048NICHD NIH HHS R01 HD036916NICHD NIH HHS R01 HD039135NICHD NIH HHS R01 HD040421NICHD NIH HHS T32 HD101392NIGMS NIH HHS P20 GM103430NIGMS NIH HHS P20 GM139767NIMHD NIH HHS R01 MD015401
6 · The paper itself

Abstract

Early life adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized to buffer the effects of ELA, its role in mitigating epigenetic age acceleration remains unclear. Data from 2,039 children (49.7% female; 46.7% Black, 26.5% Hispanic, 19% White non-Hispanic) in the Future of Families and Child Wellbeing Study were included. Home threat, community threat, and parenting were measured from ages 3 to 9 (2001-2010). Epigenetic age acceleration was assessed at ages 9 and 15 (2007-2017). Positive parenting reduced the pace of epigenetic aging in contexts of low, but not high, community threat (β = .026, p = .039). Interventions across multiple socioecological systems may be necessary to prevent the biological embedding of ELA.

Indexed as

adolescenceAdversitychildhoodepigenetic agingparenting

Identifiers

PMID39763558
PMCPMC11703298

What Socratic holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.