Evidence map›Paper›PMID 39763818›Full record

ArticlebioRxiv : the preprint server for biology2024

Modeling Insights into Potential Mechanisms of Opioid-Induced Respiratory Depression within Medullary and Pontine Networks.

Wendy L Olsen, John A Hayes, Dale Shuman, Kendall F Morris, Donald C Bolser

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wendy L OlsenBreathing Research and Therapeutics (BREATHE) Center, University of Florida, Gainesville, FL.ORCID 0000-0002-7607-8096
John A HayesBreathing Research and Therapeutics (BREATHE) Center, University of Florida, Gainesville, FL.ORCID 0000-0003-2849-7672
Dale ShumanDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL.
Kendall F MorrisDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL.ORCID 0000-0001-6582-1203
Donald C BolserBreathing Research and Therapeutics (BREATHE) Center, University of Florida, Gainesville, FL.ORCID 0000-0002-4577-8954

Funding

Breathing Research and Therapeutics (BREATHE)T32HL134621 · NHLBI · UNIVERSITY OF FLORIDA · PI Gordon S. Mitchell · 2017 to 2026
$3.4M
Central and Peripheral Regulation of Laryngeal AdductionR01HL163008 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, PITTS, TERESA G · 2022 to 2025
$2.8M
Influence of Opioids on the Brainstem Respiratory NetworkR01HL155721 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, MORRIS, KENDALL FRANCIS · 2021 to 2024
$2.7M
NHLBI NIH HHS R01 HL155721NHLBI NIH HHS R01 HL163008NHLBI NIH HHS T32 HL134621
6 · The paper itself

Abstract

The opioid epidemic is a pervasive health issue and continues to have a drastic impact on the United States. This is primarily because opioids cause respiratory suppression and the leading cause of death in opioid overdose is respiratory failure (

Indexed as

fentanylglutamate releasemedullamodelingmu-opioid receptorsmu-OROIRDopioidsponspreBötzinger Complexμ-OR

Identifiers

PMID39763818
PMCPMC11702709

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.