Evidence map›Paper›PMID 39763913›Full record

ArticlebioRxiv : the preprint server for biology2025

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency.

Vinod Tiwari, Byungchang Jin, Olivia Sun, Edwin D J Lopez Gonzalez, Min-Hsuan Chen, Xiwei Wu, Hardik Shah, Andrew Zhang, Mark A Herman, Cassandra N Spracklen and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Vinod TiwariBeckman Research Institute of City of Hope; Duarte, USA.ORCID 0000-0003-2341-0953
Byungchang JinLiver Center and Endocrine Unit, Massachusetts General Hospital; Boston, USA.ORCID 0000-0003-3184-5332
Olivia SunBeckman Research Institute of City of Hope; Duarte, USA.
Edwin D J Lopez GonzalezBeckman Research Institute of City of Hope; Duarte, USA.ORCID 0009-0008-7580-8617
Min-Hsuan ChenBeckman Research Institute of City of Hope; Duarte, USA.
Xiwei WuBeckman Research Institute of City of Hope; Duarte, USA.
Hardik ShahComprehensive Cancer Center, University of Chicago; Chicago, USA.
Andrew ZhangLiver Center and Endocrine Unit, Massachusetts General Hospital; Boston, USA.
Mark A HermanBaylor College of Medicine; Houston, USA.ORCID 0000-0001-6979-103X
Cassandra N SpracklenDepartment of Biostatistics and Epidemiology, University of Massachusetts; Amherst, USA.ORCID 0000-0003-3590-7182
Russell P GoodmanLiver Center and Endocrine Unit, Massachusetts General Hospital; Boston, USA.ORCID 0009-0003-7102-9433
Charles BrennerBeckman Research Institute of City of Hope; Duarte, USA.ORCID 0000-0002-4955-3226

Funding

Small Animal Studies CoreP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · 1985 to 2025
$31.1M
Genetic programming of human islet metabolic and endoplasmic reticulum (ER) stress responses in diabetesR01DK118011 · NIDDK · JACKSON LABORATORY · 2022 to 2025
$3.2M
Type 2 diabetes risk variant effects on mitochondrial (patho)physiologyR01DK136671 · JACKSON LABORATORY · 2025 to 2025
$740k
An NADH-ChREBP axis in fatty liver disease and dyslipidemiaR01DK134675 · MASSACHUSETTS GENERAL HOSPITAL · 2025 to 2025
$472k
NCI NIH HHS P30 CA033572NHLBI NIH HHS R01 HL147545NIDDK NIH HHS R01 DK100425NIDDK NIH HHS R01 DK118011NIDDK NIH HHS R01 DK134675NIDDK NIH HHS R01 DK136671
6 · The paper itself

Abstract

Citrin Deficiency (CD) is caused by inactivation of SLC25A13, a mitochondrial membrane protein required to move electrons from cytosolic NADH to the mitochondrial matrix in hepatocytes. People with CD do not like sweets. We discovered that SLC25A13 loss causes accumulation of glycerol-3-phosphate (G3P), which activates carbohydrate response element binding protein (ChREBP) to transcribe FGF21, which acts in the brain to restrain intake of sweets and alcohol, and to transcribe key genes of

Identifiers

PMID39763913
PMCPMC11703153

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.