Evidence map›Paper›PMID 39763956›Full record

ArticlebioRxiv : the preprint server for biology2024

Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers.

Matthew R Lum, Sachin H Patel, Hannah K Graham, Mengya Zhao, Yujuan Yi, Liang Li, Melissa Yao, Anna La Torre, Luca Della Santina, Ying Han and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Matthew R LumDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Sachin H PatelDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Hannah K GrahamDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Mengya ZhaoDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Yujuan YiDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Liang LiDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA.
Melissa YaoDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Anna La TorreDepartment of Cell Biology and Human Anatomy, School of Medicine, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0003-2103-4376
Luca Della SantinaCollege of Optometry, University of Houston, Houston, TX, 77004, USA.
Ying HanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Yang HuDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, 94304, USA.ORCID 0000-0002-7980-1649
Derek S WelsbieViterbi Family Department of Ophthalmology, University of California San Diego, San Diego, CA 92037, USA.
Xin DuanDepartment of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.ORCID 0000-0001-5260-8972

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 1985 to 2024
$16.8M
Mechanisms Underlying Type II Cadherin Guided Assembly of Retinal CircuitsR01EY030138 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Xin Duan · 2020 to 2026
$3.2M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY030138
6 · The paper itself

Abstract

Neurons use cell-adhesion molecules (CAMs) to interact with other neurons and the extracellular environment: the combination of CAMs specifies migration patterns, neuronal morphologies, and synaptic connections across diverse neuron types. Yet little is known regarding the intracellular signaling cascade mediating the CAM recognitions at the cell surface across different neuron types. In this study, we investigated the neural developmental role of Afadin

Indexed as

AfadinAmacrine CellsCell adhesionNeuronal MigrationRetinaRetinal Ganglion Cells

Identifiers

PMID39763956
PMCPMC11703203

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.