Evidence map›Paper›PMID 39763980›Full record

ArticlebioRxiv : the preprint server for biology2025

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses.

Jordan T Becker, Clayton K Mickelson, Lauren M Pross, Autumn E Sanders, Esther R Vogt, Frances K Shepherd, Chloe Wick, Alison J Barkhymer, Stephanie L Aron, Elizabeth J Fay and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jordan T BeckerDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.ORCID 0000-0002-0239-5443
Clayton K MickelsonDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Lauren M ProssDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Autumn E SandersDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Esther R VogtDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Frances K ShepherdDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Chloe WickDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Alison J BarkhymerDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Stephanie L AronDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Elizabeth J FayDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.
Reuben S HarrisDepartment of Biochemistry and Structural Biology, University of Texas Health, San Antonio, TX, USA, 78229.ORCID 0000-0002-9034-9112
Ryan A LangloisDepartment of Microbiology and Immunology, University of Minnesota - Twin Cities, Minneapolis, MN, USA, 55455.

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00017 · NIAID · EMORY UNIVERSITY · PI LOWEN, ANICE · 2021 to 2025
$27.3M
Early Responses to Influenza A Virus Replication In VivoR01AI148669 · NIAID · UNIVERSITY OF MINNESOTA · PI LANGLOIS, RYAN · 2020 to 2024
$2.5M
Harnessing ZBP1-driven cell death to improve influenza vaccine efficacyR56AI150965 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, LANGLOIS, RYAN · 2021 to 2021
$848k
APOBEC PROTEINS AND RIBOVIRAL RESTRICTIONF32AI147813 · NIAID · UNIVERSITY OF MINNESOTA · PI BECKER, JORDAN T · 2019 to 2021
$192k
NIAID NIH HHS 75N93021C00017NIAID NIH HHS F32 AI147813NIAID NIH HHS R01 AI148669NIAID NIH HHS R56 AI150965
6 · The paper itself

Abstract

Zoonotic viruses are an omnipresent threat to global health. Influenza A virus (IAV) transmits between birds, livestock, and humans. Proviral host factors involved in the cross-species interface are well known. Less is known about antiviral mechanisms that suppress IAV zoonoses. We observed CpG dinucleotide depletion in human IAV relative to avian IAV. Notably, human ZAP selectively depletes CpG-enriched viral RNAs with its cofactor KHNYN. ZAP is conserved in tetrapods but we uncovered that avian species lack KHNYN. We found that chicken ZAP may not affect IAV (PR8) or CpG enriched IAV (PR8

Identifiers

PMID39763980
PMCPMC11703154

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.