Evidence map›Paper›PMID 39764041›Full record

ArticlebioRxiv : the preprint server for biology2024

Impact of Proximal Tubule-Specific Deletion of Dipeptidyl Peptidase 4 on Blood Pressure, Renal Sodium Handling, and NHE3 Phosphorylation.

Flavia L Martins, Joao Carlos Ribeiro-Silva, Erika Fernandes de Jesus, Ravi Nistala, Adriana C C Girardi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Flavia L MartinsLaboratorio de Genética e Cardiologia Molecular, Faculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Joao Carlos Ribeiro-SilvaState University of New York (SUNY) Upstate Medical University, Syracuse, NY, USA.
Erika Fernandes de JesusLaboratorio de Genética e Cardiologia Molecular, Faculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID 0000-0002-8442-9298
Ravi NistalaDivision of Nephrology, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.ORCID 0000-0001-9577-8074
Adriana C C GirardiLaboratorio de Genética e Cardiologia Molecular, Faculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID 0000-0003-3715-6917

Funding

Role of DPP4 in Kidney Inflammation and InjuryK08DK115886 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI NISTALA, RAVI · 2019 to 2023
$848k
NIDDK NIH HHS K08 DK115886
6 · The paper itself

Abstract

Dipeptidyl peptidase 4 (DPP4) is a transmembrane serine exopeptidase abundantly expressed in the kidneys, predominantly in the proximal tubule (PT); however, its non-enzymatic functions in this nephron segment remain poorly understood. While DPP4 physically associates with the Na

Indexed as

angiotensin IIblood pressuredipeptidyl peptidase 4natriuresisNHE3proximal tubule

Identifiers

PMID39764041
PMCPMC11703172

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.