ArticleResearch square2024
Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.
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Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed.
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Authors and funding
31 authors.
Marlena FejzoDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.ORCID 0000-0001-6800-687X
Xinran WangDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.ORCID 0000-0001-9670-3939
Julia ZöllnerUCL EGA Institute for Women's Health, University College London, London, United Kingdom.ORCID 0000-0002-9072-9131
Natàlia Pujol-GualdoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0001-6428-8427
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1501-9030
Estonian Biobank Research Team
Sarah FinerWolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.ORCID 0000-0002-2684-4653
David A van HeelWolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.ORCID 0000-0002-0637-2265
Genes & Health Research Team
Ben BrumptonHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.ORCID 0000-0002-3058-1059
Laxmi BhattaHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.
Elizabeth A JasperVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.
Digna R Velez EdwardsVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.
Jacklyn N HellwegeVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.ORCID 0000-0001-7479-0920
Todd EdwardsVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, WA, USA.ORCID 0000-0002-6710-8708
Yuan LuoDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL 60611.ORCID 0000-0003-0195-7456
Atlas KhanDivision of Nephrology, Dept of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.ORCID 0000-0002-6651-2725
Kimber MacGibbonHyperemesis Education and Research Foundation, Clackamas, OR 97089 USA.ORCID 0000-0002-6534-3114
Yuan GaoKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031.
Gaoxiang GeKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031.ORCID 0000-0003-3189-8928
Inna AverbukhDepartment of Pathology, Stanford University, Stanford, CA, United States.
Erin SoonDepartment of Pathology, Stanford University, Stanford, CA, United States.
Michael AngeloDepartment of Pathology, Stanford University, Stanford, CA, United States.
Per MagnusNorwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-6427-4735
Stefan JohanssonMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Pål R NjølstadMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Marc VaudelMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-1179-9578
Chang ShuDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.
Nicholas MancusoDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.ORCID 0000-0002-9352-5927
Funding
Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0MTechnologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7MThe eMERGE Risk Assessment Network - Coordinating CenterU01HG011166 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Niall John Lennon, Joseph F. Peterson · 2020 to 2026
$16.8MGenomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5MFinding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6MVariation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4MOMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3MDNA Sequencing Support for the eMERGE NetworkU01HG008664 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2015 to 2019
$10.9MPacific Center for Genome ResearchU54HG013243 · NHGRI · UNIVERSITY OF HAWAII AT MANOA · PI Alexandra Margaret Lynn Binder, Youping Deng · 2023 to 2026
$10.8MGenomic risk in clinic care to promote health equity in New York City patientsU01HG011176 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI NOURA SERENE ABUL-HUSN, Eimear Elizabeth Kenny · 2020 to 2026
$10.4MUtilizing Polygenic Risk to Understand and Improve Outcomes: A Model For Overturning Health Disparities Through Minority-Enriched Genomics HealthcareU01HG011175 · NHGRI · CHILDREN'S HOSP OF PHILADELPHIA · PI Hakon Hakonarson · 2020 to 2026
$10.3MIntegrating Genomic Risk Assessment for Disease Management in a Clinical PopulationU01HG011167 · NHGRI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES J CIMINO, NITA A LIMDI · 2020 to 2026
$9.3MNCI NIH HHS R01 CA258808NHGRI NIH HHS R01 HG012133NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008664NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01 HG008673NHGRI NIH HHS U01 HG008676NHGRI NIH HHS U01 HG008679NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008684NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01 HG008701NHGRI NIH HHS U01 HG011166NHGRI NIH HHS U01 HG011167NHGRI NIH HHS U01 HG011169NHGRI NIH HHS U01 HG011172NHGRI NIH HHS U01 HG011175NHGRI NIH HHS U01 HG011176NHGRI NIH HHS U01 HG011181NHGRI NIH HHS U54 HG013243NIAMS NIH HHS K12 AR084232NIEHS NIH HHS N01 ES075558NIGMS NIH HHS R01 GM140287NIMHD NIH HHS U54 MD007593NINDS NIH HHS U01 NS047537Wellcome Trust
Abstract
While most pregnancies are affected by nausea and vomiting, hyperemesis gravidarum (HG) is at the severe end of the clinical spectrum and is associated with dehydration, undernutrition, and adverse maternal, fetal, and child outcomes. Herein we performed a multi-ancestry genome-wide association study (GWAS) of severe nausea and vomiting of pregnancy of 10,974 cases and 461,461 controls across European, Asian, African, and Latino ancestries. We identified ten significantly associated loci, of which six were novel (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.