Evidence map›Paper›PMID 39764188›Full record

ReviewInternational journal of nanomedicine2024

Bioactive Materials Facilitate the Restoration of Neurological Function Post Cerebral Ischemic Stroke.

Chunyan Wang, Chao Sun, Ziyan Ding, Xiujuan Wu, Kangding Liu, Jie Cao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  5. Engineering microspheres for breast cancer: integrating tumor modeling, diagnostics, and targeted treatment.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunyan Wang *Department of Neurology, Neurology Specialist Hospital, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Chao Sun *Department of Orthopedic Surgery, Orthopedic Center, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Ziyan DingDepartment of Neurology, Neurology Specialist Hospital, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Xiujuan WuDepartment of Neurology, Neurology Specialist Hospital, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Kangding LiuDepartment of Neurology, Neurology Specialist Hospital, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.
Jie CaoDepartment of Neurology, Neurology Specialist Hospital, The First Hospital of Jilin University, Jilin University, Changchun, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recovery process following ischemic stroke is a complex undertaking involving intricate cellular and molecular interactions. Cellular dysfunction or aberrant pathways can lead to complications such as brain edema, hemorrhagic transformation, and glial scar hyperplasia, hindering angiogenesis and nerve regeneration. These abnormalities may contribute to long-term disability post-stroke, imposing significant burdens on both families and society. Current clinical interventions primarily focus on endovascular therapy, overlooking the protection of brain cells themselves. However, the use of bioactive materials in stroke management has shown notable safety and efficacy. By precisely targeting the ischemic site at a cellular and molecular level, this therapeutic approach mitigates ischemia-induced brain tissue damage and promotes site repair. This review examines the protective benefits of bioactive materials in reducing cell damage and facilitating nerve restoration in accordance with the pathophysiological basis of ischemic stroke. Enhanced understanding of ischemic stroke mechanisms has the potential to advance the targeted and efficient clinical use of bioactive materials.

Indexed as

Ischemic StrokeAnimalsBiocompatible MaterialsBrainBrain IschemiaHumansNeuroprotective AgentsRecovery of FunctionBiocompatible MaterialsNeuroprotective Agentsangiogenesisbioactive materialsinflammationischemic strokenerve regenerationoxidative stress

Identifiers

PMID39764188
PMCPMC11701096

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.