SynthesisFrontiers in nutrition2024
Prognostic significance of preoperative prognostic nutritional index in hepatocellular carcinoma after curative hepatectomy: a meta-analysis and systemic review.
Synthesis in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07395635 (Impact of Immunonutrition in Patients Undergoing Hepatectomies for Liver Tumors), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Immunonutrition in Patients Undergoing Hepatectomies for Liver Tumors: A Randomized Controlled Phase II Trial
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prognostic Nutritional Index and Cancer Prognostic Outcomes: An Umbrella Review of Systematic Reviews and Meta-analyses of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- Preoperative gamma-glutamyltransferase-to-lymphocyte ratio and prognosis after curative hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis.BMC gastroenterology · 2026Pooled it
- Prognostic value of prognostic nutritional index in patients with hepatocellular carcinoma undergoing hepatectomy: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Prognostic value of Prognostic Nutritional Index in cancer: an umbrella review of systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Association between the Prognostic Nutritional Index and survival outcomes in hepatocellular carcinoma patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis.Translational cancer research · 2026Review
- Combined preoperative PNI and APRI for risk stratification after curative hepatectomy for hepatocellular carcinoma.BMC gastroenterology · 2026Article
- Development and validation of a model for predicting short-term complications after hepatectomy in patients with primary liver cancer.Journal of gastrointestinal oncology · 2026Article
- The Role of Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Predicting Outcomes of Chinese Patients with Diabetic Foot Ulcers After Moist Exposed Burn Ointment Treatment.International journal of general medicine · 2026Article
- A blood-biomarker based CTC-ALRI score predicts recurrence in hepatocellular carcinoma patients following curative resection.Frontiers in oncology · 2026Article
- Development of a PNI-Based Prognostic Model for Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib-Based Triple Therapy.Journal of hepatocellular carcinoma · 2026Article
- Nomogram Based on Tumor Burden Score and Inflammation-Nutritional Indicators to Predict the Prognosis of Hepatocellular Carcinoma Patients Undergoing TACE Combined with Targeted and Immunotherapy.Journal of hepatocellular carcinoma · 2026Article
- Changes in nutritional status in hepatocellular carcinoma patients treated with sorafenib.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Prognostic nutritional index as an early predictor of mortality in patients with severe fever with thrombocytopenia syndrome: multicenter retrospective study in South Korea.BMC infectious diseases · 2025Article
- Evaluating the prognostic significance of the modified prognostic nutritional index-C-reactive protein-to-albumin-to-lymphocyte index in acute decompensated heart failure: special attention to the impact of diabetes.Frontiers in nutrition · 2025Article
- Prognostic nutritional index as a predictor of in-hospital mortality in neonates and infants undergoing cardiac surgery.Frontiers in nutrition · 2025Article
- The impact of body composition and systemic inflammatory markers on postoperative complications in early-stage cervical cancer.Frontiers in oncology · 2025Article
- The Clinical Impact of Prognostic Nutritional Index at Recurrence of Pancreatic Cancer.Cancer diagnosis & prognosisArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The Prognostic Nutritional Index (PNI), which reflects both nutritional and immune status, has emerged as a potential predictor of survival outcomes in cancer patients. However, its role in forecasting the prognosis of hepatocellular carcinoma (HCC) following curative hepatectomy remains unclear. To further investigate the association between PNI and survival outcomes in HCC patients, we conducted a systematic review and meta-analysis. Methods: We performed a comprehensive search across Web of Science, PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure to identify studies evaluating the prognostic value of PNI in HCC following curative hepatectomy. Overall survival (OS), recurrence-free survival (RFS), and disease-free survival (DFS) were extracted as primary outcomes. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed-effect or random-effect models. Additionally, heterogeneity, publication bias, and sensitivity analyses were performed to evaluate the consistency and robustness of the obtained results. Results: This systematic review and meta-analysis included 19 studies comprising a total of 9,830 patients. The results indicated that higher PNI was significantly associated with longer overall survival (OS) ( Conclusion: Preoperative PNI is a significant prognostic indicator in HCC patients undergoing curative hepatectomy, with higher PNI correlating with improved survival outcomes. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024530150, identifier CRD42024530150.
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