Evidence map›Paper›PMID 39765337›Full record

ArticleInternational neurourology journal2024

Effect of Eugenol on Detrusor Muscle: Potential for Overactive Bladder Treatment.

Marília Cavalcante Araújo, Átila Pereira-Gonçalves, André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Luís Peireira-de-Morais, Francisco Sydney Henrique-Félix, Nicoly Câmara Castro Sousa-Júlio, José Henrique Leal-Cardoso, Andrelina Noronha Coelho-de-Souza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International neurourology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. L-Type Voltage-Gated CaMedical sciences (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Innovation and the Importance of Patient-Centered Treatment.International neurourology journal · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marília Cavalcante AraújoExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Átila Pereira-GonçalvesFaculty of Education and Integrated Science, State University of Ceará, Crateús, Brazil.
André Nogueira Cardeal Dos SantosExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
José Ednésio da Cruz FreireLaboratory of Biochemistry and Gene Expression, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Luís Peireira-de-MoraisDepartment of Biological Chemistry, Regional University of Cariri, Crato, Brazil.
Francisco Sydney Henrique-FélixExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Nicoly Câmara Castro Sousa-JúlioExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
José Henrique Leal-CardosoElectrophysiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Andrelina Noronha Coelho-de-SouzaExperimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis investigation was conducted to elucidate the effects of eugenol on bladder contractility through experimental and in silico approaches.

methodsTo assess the impact of eugenol on muscular contractility, longitudinal strips of bladder tissue, measuring 2 mm by 6 mm, were mounted in perfusion chambers connected to an isometric force transducer. Furthermore, molecular docking studies were conducted to explore the potential of eugenol to target the M3 muscarinic acetylcholine receptor (M3R) and voltage-operated calcium channels (VOCCs) in muscle cells, utilizing in silico techniques.

resultsEugenol exhibited a concentration-dependent inhibitory effect on both the phasic and tonic components of the contraction induced by 60mM K+ and carbachol, completely suppressing this contraction at a concentration of 3mM. Additionally, eugenol inhibited the concentration-contraction curve elicited by Ba2+.

conclusionThe in vitro and in silico results suggest that the mechanism of eugenol likely involves blockade of VOCCs and/or M3R, implicating eugenol as a promising molecule for the treatment of overactive bladder.

Indexed as

Calcium channelEugenol, DetrusorM3 receptorOveractive bladderSmooth muscle

Identifiers

PMID39765337
PMCPMC11710953

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.