Evidence mapPaperPMID 39765902Full record

ArticleAntioxidants (Basel, Switzerland)2024

Increased Adhesiveness of Blood Cells Induced by Mercury Chloride: Protective Effect of Hydroxytyrosol.

Pasquale Perrone, Raquel Ortega-Luna, Caterina Manna, Ángeles Álvarez-Ribelles, Victor Collado-Diaz

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Clarified açaí (Euterpe oleracea Martius) exerts protective effects against methylmercury toxicity in salivary glands and total saliva.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Frontiers in nutrition · 2026
    Article
  8. Review
  9. Review
  10. Cytoprotective Potential ofInternational journal of molecular sciences · 2025
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pasquale PerroneDepartment of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Raquel Ortega-LunaDepartamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain.
Caterina MannaDepartment of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-9603-0017
Ángeles Álvarez-RibellesDepartamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain.ORCID 0000-0002-2301-9746
Victor Collado-DiazDepartamento de Farmacología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain.ORCID 0000-0003-2981-4385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mercury (Hg) is a highly toxic environmental contaminant that can harm human health, ultimately leading to endothelial dysfunction. Hg toxicity is partially mediated by the exposure of the cell membrane's surface of erythrocytes (RBCs) to phosphatidylserine (PS). In the context of these challenges, hydroxytyrosol, a phenolic compound of olive oil, has the ability to mitigate the toxic effects of Hg. This study aims to analyze the effect of Hg on the adhesion of RBCs and polymorphonuclear cells (PMNs) to the vascular endothelium and the potential protective effect of hydroxytyrosol, as these interactions are crucial in the development of cardiovascular diseases (CVDs). RBCs, PMNs, and human vein endothelial cells (HUVECs) were treated with increasing concentrations of HgCl

Indexed as

adhesionerythrocyteshydroxytyrosolmercuryneutrophilstoxicity

Identifiers

PMID39765902
PMCPMC11673208

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.