Evidence mapPaperPMID 39766138Full record

ReviewCancers2024

New Relevant Evidence in Cholangiocarcinoma Biology and Characterization.

Nunzia Porro, Elena Spínola-Lasso, Mirella Pastore, Alessandra Caligiuri, Luca di Tommaso, Fabio Marra, Alessandra Gentilini

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nunzia PorroDepartment of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy.
Elena Spínola-LassoDepartment of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy.ORCID 0000-0003-2207-5786
Mirella PastoreDepartment of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy.ORCID 0000-0003-0938-3266
Alessandra CaligiuriDepartment of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy.
Luca di TommasoDepartment of Biomedical Sciences, Humanitas University, 20089 Milan, Italy.ORCID 0000-0002-9013-4728
Fabio MarraDepartment of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-8629-0878
Alessandra GentiliniDepartment of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy.ORCID 0000-0001-7692-390X

Funding

PRIN 2022 2022PNZ9KP
6 · The paper itself

Abstract

Among solid tumors, cholangiocarcinoma (CCA) emerges as one of the most difficult to eradicate. The silent and asymptomatic nature of this tumor, particularly in its early stages, as well as the high heterogeneity at genomic, epigenetic, and molecular levels delay the diagnosis, significantly compromising the efficacy of current therapeutic options and thus contributing to a dismal prognosis. Extensive research has been conducted on the molecular pathobiology of CCA, and recent advances have been made in the classification and characterization of new molecular targets. Both targeted therapy and immunotherapy have emerged as effective and safe strategies for various types of cancers, demonstrating potential benefits in advanced CCA. Furthermore, the deeper comprehension of the cellular and molecular components in the tumor microenvironment (TME) has opened up possibilities for new innovative treatment methods. This review discusses recent evidence in the characterization and molecular biology of CCA, highlighting novel possible druggable targets.

Indexed as

cholangiocarcinomaclassificationgut microbiotalong non-coding RNAsenescencetherapytumor microenvironment

Identifiers

PMID39766138
PMCPMC11674836

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.