Evidence map›Paper›PMID 39766315›Full record

ArticleBiomolecules2024

Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia.

Anastasia Garoufi, Maria Papadaki, Michalis Kalogiannis, Urania Zerva, Marietta Charakida, Antonios Marmarinos, Achilleas Attilakos

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The effects of terpenes on metabolism: a comprehensive review on recent updates.Current opinion in clinical nutrition and metabolic care · 2025
    Review
  2. Frontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anastasia GaroufiLipid Outpatient Unit, 2nd Department of Pediatrics, Medical School, National and Kapodistrian University of Athens (NKUA), "P. & A. Kyriakou" Children's Hospital, Thivon & Levadias Str., 11527 Athens, Greece.
Maria PapadakiLipid Outpatient Unit, 2nd Department of Pediatrics, Medical School, National and Kapodistrian University of Athens (NKUA), "P. & A. Kyriakou" Children's Hospital, Thivon & Levadias Str., 11527 Athens, Greece.
Michalis KalogiannisThird Department of Pediatrics, Medical School, National and Kapodistrian University of Athens (NKUA), "Attikon" General Hospital, 12462 Athens, Greece.
Urania ZervaNutrition Department, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece.
Marietta CharakidaLipid Outpatient Unit, 2nd Department of Pediatrics, Medical School, National and Kapodistrian University of Athens (NKUA), "P. & A. Kyriakou" Children's Hospital, Thivon & Levadias Str., 11527 Athens, Greece.
Antonios MarmarinosLaboratory of Clinical Biochemistry-Molecular Diagnostic, 2nd Department of Pediatrics, Medical School, National and Kapodistrian University of Athens (NKUA), "P. & A. Kyriakou" Children's Hospital, 24 Mesogeion Avn, 11527 Athens, Greece.
Achilleas AttilakosThird Department of Pediatrics, Medical School, National and Kapodistrian University of Athens (NKUA), "Attikon" General Hospital, 12462 Athens, Greece.ORCID 0000-0002-8032-9994

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to evaluate the efficacy and safety of the long-term use of a dietary supplement containing red yeast rice (RYR), combined with other natural compounds, in children and adolescents with primary hypercholesterolemia. A nutraceutical, containing RYR, policosanols, coenzyme Q10, astaxanthin and folic acid (commercial name: Armolipid), was administered once daily in 84 children/adolescents with moderate or severe primary hypercholesterolemia. Moreover, 19 of the participants consumed 1.5-2.5 g of phytosterols daily until the initiation of dietary supplementation with Armolipid. Clinical and laboratory evaluation took place before and 6 and 16 months after treatment. Nutraceutical consumption resulted in a significant decrease in total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and apolipoprotein B levels, which was maintained with long-term administration (

Indexed as

Dietary SupplementsHypercholesterolemiaAdolescentBiological ProductsChildCholesterolCholesterol, LDLFatty AlcoholsFemaleFolic AcidHumansLipidsMalePhytosterolsTriglyceridesUbiquinoneastaxanthineBiological ProductsCholesterolCholesterol, LDLcoenzyme Q10Fatty AlcoholsFolic AcidLipidsPhytosterolspolicosanolred yeast riceTriglyceridesUbiquinoneXanthophyllsdyslipidemialipid profilenutraceuticalsphytosterolsred yeast rice

Identifiers

PMID39766315
PMCPMC11674530

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.