Evidence map›Paper›PMID 39766363›Full record

ArticleBrain sciences2024

Noninvasive Ultra Low Intensity Light Photodynamic Treatment of Glioblastoma with Drug Augmentation: LoGlo PDT Regimen.

Richard E Kast, Anton P Kast, Jürgen Arnhold, Felix Capanni, Laura N Milla Sanabria, Nicolas Bader, Bruno Marques Vieira, Alex Alfieri, Georg Karpel-Massler, Erasmo Barros da Silva

Abstract read
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In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richard E KastIIAIGC Study Center, 11 Arlington Ct, Burlington, VT 05408, USA.ORCID 0000-0002-7876-0400
Anton P KastIIAIGC Study Center, 11 Arlington Ct, Burlington, VT 05408, USA.
Jürgen ArnholdInstitute for Medical Physics and Biophysics, University of Leipzig, Härtelstrasse 16-18, 04107 Leipzig, Germany.
Felix CapanniBiomechatronics Research Group, Ulm University of Applied Sciences, Albert Einstein Allee 55, 89081 Ulm, Germany.ORCID 0009-0001-7951-3700
Laura N Milla SanabriaINBIAS, Universidad Nacional de Río Cuarto-CONICET, Río Cuarto 5800, Argentina.ORCID 0000-0002-8689-9736
Nicolas BaderBiomechatronics Research Group, Ulm University of Applied Sciences, Albert Einstein Allee 55, 89081 Ulm, Germany.ORCID 0000-0002-1268-8119
Bruno Marques VieiraLaboratório de Biomedicina do Cérebro, Instituto Estadual do Cérebro, Rio de Janeiro 20230-024, Brazil.ORCID 0000-0002-0697-4311
Alex AlfieriDepartment of Neurosurgery, Cantonal Hospital of Winterthur, 8400 Winterthur, Switzerland.ORCID 0000-0002-0209-4114
Georg Karpel-MasslerDepartment of Neurosurgery, Ulm University Hospital, 89081 Ulm, Germany.
Erasmo Barros da SilvaNeurosurgery Department-Neuro-Oncology, Instituto de Neurologia de Curitiba, Rua Jeremias Maciel Perretto, 300-Campo Comprido, Curitiba 81210-310, Brazil.ORCID 0000-0002-0454-3825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper presents the basis for LoGlo PDT, a new treatment for glioblastoma. Glioblastoma is currently treated with maximal safe resection, temozolomide, and ionizing irradiation. Mortality in 2024 remains over 80% within several years from diagnosis. Oral 5-aminolevulinic acid (5-ALA) is an FDA/EMA approved drug that is selectively taken up by malignant cells, including by glioblastoma. In photodynamic treatment of glioblastoma, intense intraoperative light causes glioblastoma tissue that has taken up 5-ALA to generate cytotoxic reactive oxygen species. The requirement for intense light flux has restricted photodynamic treatment to a single one-hour intraoperative session. We analyze here published data showing that external light, illuminating the entire intact scalp, can attain low μW/cm

Indexed as

5-ALAglioblastomanoninvasivephotodynamic treatmentrepurposing

Identifiers

PMID39766363
PMCPMC11674893

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.