ArticleFoods (Basel, Switzerland)2024
The Antidiabetic Effect of Grape Skin Extracts of Selected Indigenous Croatian White Grapevine Varieties.
Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Reutilization of berry by-products for green food additives: a comprehensive review and future perspectives.NPJ science of food · 2026Review
- Exploring the Bioavailability of Red Grape Skin Extract Polyphenols: A Caco-2 Cell Model Study.Foods (Basel, Switzerland) · 2025Article
- Insights on the Health Benefits and Functional Potential of Food Bioactive Compounds.Foods (Basel, Switzerland) · 2025Article
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Authors and funding
5 authors.
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Abstract
Grape skin is an excellent bioactive compound source with numerous beneficial health effects. This study aimed to determine and compare the antidiabetic potential of the grape skin of indigenous Croatian white grapevine varieties. The grape skin extracts (GSEs) were assessed for total polyphenols, antioxidant activity, and inhibition potential against α-amylase and α-glucosidase, enzymes responsible for carbohydrate metabolism. GSE of variety "Svetokriška belina" has the highest total phenols (TP) content (1404.87 mg of gallic acid equivalent), the highest antioxidant capacity against DPPH (544.82 mg ascorbic acid equivalent), and the highest inhibitory activity against α-amylase (99.60%). α-glucosidase was best inhibited by the variety "Kozjak" (93.53%), followed by a significantly lower inhibition by the GSE of "Svetokriška belina" (89.64%). The principal component analysis (PCA) revealed the relationship among the grape varieties by their inhibition potential, where the first PC explained 71.34% of the variation. Indigenous Croatian white grapevine varieties have great potential for developing new natural supplements to prevent and treat diabetes.
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