Evidence map›Paper›PMID 39767135›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection.

Rachel Pakan, Roham Hadidchi, Yousef Al-Ani, Hannah Piskun, Katie S Duong, Sonya Henry, Stephen Wang, Carine W Maurer, Tim Q Duong

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. COVID-19 and Radiological Progression of Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2026
    Article
  3. Observational
  4. Article
  5. Neuropsychiatric, stress-related symptoms and essential tremor clinical variability.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  6. Five-year cardiovascular outcomes following COVID-19-associated carditis.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel PakanDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Roham HadidchiDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Yousef Al-AniDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Hannah PiskunDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Katie S DuongDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Sonya HenryDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.ORCID 0000-0002-6471-4569
Stephen WangDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.
Carine W MaurerDepartment of Neurology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Tim Q DuongDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA.ORCID 0000-0001-6403-2827

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesAlthough COVID-19 has been linked to worse outcomes in patients with neurological disorders, its impact on those with essential tremor (ET) remains unclear. To investigate clinical outcomes of ET patients with and without COVID-19 three and a half years post-pandemic.

methods1074 ET patients were evaluated in this retrospective study in the Montefiore Health System from January 2016 to July 2023. Comparisons between ET patients with and without a positive SARS-CoV-2 polymerase chain reaction test were made. Outcomes included post-index date major adverse cardiovascular events (MACEs), new-onset sleep disturbances, fatigue, dyspnea, first-time fall, new-onset anxiety, new-onset depression, headache, new-onset imbalance, new-onset mild cognitive impairment, and all-cause mortality, adjusted hazard ratios (aHR) adjusting for covariates were calculated.

resultsET patients with COVID-19 had higher prevalence of pre-existing type-2 diabetes, depression, and anxiety compared to ET patients without COVID-19. COVID-19 was significantly associated with higher risk of MACEs, (aHR = 2.39 [1.49, 3.82]), new-onset sleep disturbance, (aHR = 2.12 [1.44, 3.13]), fatigue, (aHR = 1.83 [1.27, 2.65]), dyspnea, (aHR = 1.98 [1.40, 2.80]), first-time fall, (aHR = 4.76 [2.24, 10.14]), new-onset anxiety, (aHR = 3.66 [2.02, 6.64]), and new-onset depression, (aHR = 2.38 [1.20, 4.70]). COVID-19 was not associated with all-cause mortality.

conclusionsIn patients with ET, COVID-19 significantly increases the risk of several long-term adverse health outcomes, but not mortality.

Indexed as

essential tremorlong COVIDneurodegenerative diseasesPASC

Identifiers

PMID39767135
PMCPMC11674104

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.