ArticleBiomedicines2024
Sex-Dependent Differences in the Elemental Composition of Internal Organs Determined via Total Reflection X-Ray Fluorescence and Inductively Coupled Plasma Optical Emission Spectroscopy.
Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Sex differences in potassium regulation: evidence, molecular mechanisms and clinical implications.Biology of sex differences · 2026Review
- Elemental and biomolecular changes in serum as indicators of SPION action in the body: analysis using TXRF, FTIR and Raman spectroscopy.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch on elemental changes in tissues and organs provides valuable information enabling better understanding of the physiological processes occurring in a living organism, as well as the pathogenesis and course of various diseases. They may also contribute to the development of new, more effective, and safer therapeutic strategies. So far, they have been carried out mainly on male individuals because of the easier planning and conducting of experiments as well as the lower variability of the results in comparison with studies involving females.
methodsThe significance of incorporating both sexes in research concerning elemental alterations of tissues may be unveiled by data concerning the influence of sex on the physiological levels of selected elements in various rat organs. Therefore, here we determined and compared the levels of P, S, K, Ca, Fe, Cu, Zn, and Se in brains, hearts, kidneys, livers, and spleens taken from male and female rats. To measure the concentrations of the elements in digested tissue samples, ICP-OES and TXRF methods were utilized.
resultsSignificant differences between male and female rats were found for all the organs examined, and the concentrations of most of the tested elements were higher in males than females. The exception was Fe, the level of which in the kidneys and liver was higher in female rats. Sex influenced the elemental composition of spleen the most. For the brain, heart, kidneys, and liver, differences were sparse and were found mainly for the heavier elements.
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