Evidence map›Paper›PMID 39767816›Full record

ReviewBiomedicines2024

Bile Acids in Inflammatory Bowel Disease: From Pathophysiology to Treatment.

Samantha H Bai, Arun Chandnani, Siyan Cao

Abstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Bile acids as therapeutic agents.Frontiers in pharmacology · 2025
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samantha H BaiDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1846-2583
Arun ChandnaniDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Siyan CaoDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-3740-2164

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
CLINICAL/LABORATORY TRAINING ACADEMIC GASTROENTEROLOGYT32DK007130 · NIDDK · WASHINGTON UNIVERSITY · PI MATTHEW AARON CIORBA · 1986 to 2026
$8.3M
Endoplasmic Reticulum Stress Controls Innate Lymphoid Cells in Intestinal InflammationK08DK140612 · NIDDK · WASHINGTON UNIVERSITY · PI Siyan Cao · 2024 to 2026
$501k
American Gastroenterological Association AGA2023-32-03Crohn's and Colitis Foundation CCF1062472NIDDK NIH HHS K08 DK140612NIDDK NIH HHS P30 DK052574NIDDK NIH HHS T32 DK007130NIH HHS 1K08DK140612-29A1NIH HHS 5T32DK007130-51Washington University Clinical and Translational Research Funding Program CTRFP1714Washington University DDRCC NIDDK P30 DK052574
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This review discusses the latest discoveries in the roles BAs play in IBD pathogenesis and explores how these discoveries offer promising new therapeutic targets to treat IBD and improve patient outcomes. Several therapies discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, and mesenchymal stem cell therapies that have all been shown to decrease IBD disease activity.

Indexed as

bile acidsCrohn’s diseaseinflammatory bowel diseasenew therapiespathogenesisulcerative colitis

Identifiers

PMID39767816
PMCPMC11673883

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.