Advancing 3D Engineered In Vitro Models for Heart Failure Research: Key Features and Considerations.

Elisa C H van Doorn, Jorik H Amesz, Olivier C Manintveld, Natasja M S de Groot, Jeroen Essers, Su Ryon Shin, Yannick J H J Taverne

Abstract readReview

PubMed Full text at PMC Publisher

In one paragraph

Review in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elisa C H van DoornTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.

Jorik H AmeszTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-0305-1271

Olivier C ManintveldDepartment of Cardiology, Cardiovascular Institute, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-2202-7314

Natasja M S de GrootDepartment of Cardiology, Cardiovascular Institute, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-0259-6691

Jeroen EssersDepartment of Molecular Genetics, Erasmus Medical Centre, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-0605-7211

Su Ryon ShinDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Yannick J H J TaverneTranslational Cardiothoracic Surgery Research Lab, Department of Cardiothoracic Surgery, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure is characterized by intricate myocardial remodeling that impairs the heart's pumping and/or relaxation capacity, ultimately reducing cardiac output. It represents a major public health burden, given its high prevalence and associated morbidity and mortality rates, which continue to challenge healthcare systems worldwide. Despite advancements in medical science, there are no treatments that address the disease at its core. The development of three-dimensional engineered

Indexed as

3D modelsbiomimetic scaffoldscardiac fibrosiscardiac tissue engineeringcell maturationextracellular matrixheart failurein vitro modelingmyocardial remodelingtranslational research

Identifiers

PMID39768038

DOI10.3390/bioengineering11121220

PMCPMC11673263

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.