Evidence map›Paper›PMID 39768062›Full record

ArticleBioengineering (Basel, Switzerland)2024

The Effect of Conditioned Medium from Angiopoietin-1 Gene-Modified Mesenchymal Stem Cells on Wound Healing in a Diabetic Mouse Model.

Qiong Deng, Shenzhen Pan, Fangzhou Du, Hongfei Sang, Zhixin Cai, Xiaoyu Xu, Qian Wei, Shuang Yu, Jingzhong Zhang, Chenglong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiong DengDepartment of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Shenzhen PanDepartment of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Fangzhou DuSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Hongfei SangDepartment of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Zhixin CaiDepartment of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.
Xiaoyu XuDepartment of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441000, China.
Qian WeiSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Shuang YuSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Jingzhong ZhangSchool of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.ORCID 0000-0003-2604-6624
Chenglong LiDepartment of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215000, China.

Funding

National Key Research and Development Program of China 2021YFA1101100National Key Research and Development Program of China 2022YFA1104800the 14th "Six Talents Peaks" Foundation of Jiangsu Province WSW-054the Fifth Gusu Health Stratification Training Youth Talents Program GSWS2019038
6 · The paper itself

Abstract

introductionMesenchymal stem cells (MSCs) have been introduced as a promising treatment for diabetic wounds. The effects of stem cell therapy are thought to be caused by bioactive molecules secreted by stem cells. Stem cell-based gene therapies can target bioactive molecules. Therefore, treatment using conditioned medium (CM) derived from genetically engineered stem cells has been proposed as an alternative option for diabetic ulcer care.

methodsMSCs derived from human umbilical cords were obtained and engineered to overexpress the angiogenin-1 gene (MSCs

resultsIn vitro assays demonstrated that MSC

conclusionThese results indicate that MSC

Indexed as

angiogenesisAngiopoietin 1conditioned mediumdiabetic wound healingmesenchymal stem cell

Identifiers

PMID39768062
PMCPMC11673525

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.