Evidence map›Paper›PMID 39768212›Full record

ArticleCells2024

Mural Cells Initiate Endothelial-to-Mesenchymal Transition in Adjacent Endothelial Cells in Extracranial AVMs.

Syed J Mehdi, Haihong Zhang, Ravi W Sun, Gresham T Richter, Graham M Strub

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Syed J MehdiArkansas Children's Research Institute (ACRI), Little Rock, AR 72202, USA.ORCID 0000-0002-2388-0480
Haihong ZhangArkansas Children's Research Institute (ACRI), Little Rock, AR 72202, USA.ORCID 0000-0002-4327-9027
Ravi W SunArkansas Children's Research Institute (ACRI), Little Rock, AR 72202, USA.
Gresham T RichterArkansas Children's Research Institute (ACRI), Little Rock, AR 72202, USA.
Graham M StrubArkansas Children's Research Institute (ACRI), Little Rock, AR 72202, USA.ORCID 0000-0002-2585-4956

Funding

Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Samrat Roy Choudhury · 2017 to 2026
$27.6M
Next Generation Treatments for Lymphatic MalformationsR01HL173107 · NHLBI · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI GRAHAM M STRUB · 2024 to 2026
$2.0M
National Institute of General Medical Sciences (NIGMS) P20GM121293NHLBI NIH HHS R01 HL173107NIGMS NIH HHS P20 GM121293NIH HHS 1R01HL173107-24S1
6 · The paper itself

Abstract

Extracranial arteriovenous malformations (eAVMs) are complex vascular lesions characterized by anomalous arteriovenous connections, vascular instability, and disruptions in endothelial cell (EC)-to-mural cell (MC) interactions. This study sought to determine whether eAVM-MCs could induce endothelial-to-mesenchymal transition (EndMT), a process known to disrupt vascular integrity, in the eAVM microenvironment. eAVM and paired control tissues were analyzed using RT-PCR for EC (

Indexed as

Arteriovenous MalformationsEndothelial CellsEpithelial-Mesenchymal TransitionAdolescentAdultChildFemaleHumansHuman Umbilical Vein Endothelial CellsMaleMiddle AgedSnail Family Transcription FactorsYoung AdultSnail Family Transcription FactorsCD31EndMTendothelial cellsextracranial arteriovenous malformationmural cellsvascular anomalyvascular instability

Identifiers

PMID39768212
PMCPMC11727354

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.