Evidence map›Paper›PMID 39768395›Full record

ArticleLife (Basel, Switzerland)2024

Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach.

Mark Widder, Chance Carbaugh, William van der Schalie, Ronald Miller, Linda Brennan, Ashley Moore, Robert Campbell, Kevin Akers, Roseanne Ressner, Monica Martin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mark WidderWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-6301-1028
Chance CarbaughWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
William van der SchalieWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Ronald MillerWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Linda BrennanWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Ashley MooreWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0009-0002-8459-7264
Robert CampbellWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-8745-2805
Kevin AkersAudie L. Murphy VA Medical Center, San Antonio, TX 78229, USA.ORCID 0000-0001-5843-5363
Roseanne RessnerWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Monica MartinWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Michael MadejczykWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0002-6000-2599
Blair DancyWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.ORCID 0000-0001-8610-6073
Patricia LeeWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Charlotte LanteriWalter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Funding

United States Army Medical Research and Development Command NA
6 · The paper itself

Abstract

In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority. To identify potential sepsis drug candidates, we used an optimized larval zebrafish model of endotoxicity/sepsis to screen commercial libraries of drugs approved by the U.S. Food and Drug Administration (FDA) and other active pharmaceutical ingredients (APIs) known to affect pathways implicated in the initiation and progression of sepsis in humans (i.e., inflammation, mitochondrial dysfunction, coagulation, and apoptosis). We induced endotoxicity in 3- and 5-day post fertilization larval zebrafish (characterized by mortality and tail fin edema (vascular leakage)) by immersion exposure to 60 µg/mL

Indexed as

drug discoveryendotoxicitylipopolysaccharidesepsiszebrafish

Identifiers

PMID39768395
PMCPMC11676162

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.