ArticleInternational journal of molecular sciences2024
Establishment of Novel High-Grade Serous Ovarian Carcinoma Cell Line OVAR79.
Polina V Shnaider, Irina K Malyants, Olga M Ivanova, Veronika S Gordeeva, Ekaterina A Svirina, Natalya B Zakharzhevskaya, Olga Y Shagaleeva, Oksana V Selezneva, Alexandra N Bogomazova, Maria M Lukina and 4 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Polina V ShnaiderCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0003-2722-6272 Irina K MalyantsLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical and Biological Agency, 119435 Moscow, Russia.
Olga M IvanovaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0002-2383-1208 Veronika S GordeevaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Ekaterina A SvirinaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical and Biological Agency, 119435 Moscow, Russia.
Natalya B ZakharzhevskayaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical and Biological Agency, 119435 Moscow, Russia.
Olga Y ShagaleevaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical and Biological Agency, 119435 Moscow, Russia.
Oksana V SeleznevaLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical and Biological Agency, 119435 Moscow, Russia.
Alexandra N BogomazovaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0003-1549-1984 Maria M LukinaCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Olga I AleshikovaNational Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine Named After V.I. Kulakov, 117198 Moscow, Russia.
Nataliya A BabaevaNational Medical Scientific Centre of Obstetrics, Gynaecology and Perinatal Medicine Named After V.I. Kulakov, 117198 Moscow, Russia.
Andrey V SlonovLopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical and Biological Agency, 119435 Moscow, Russia.ORCID 0000-0003-4416-7315 Victoria O ShenderCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0001-9156-2938 Funding
Ministry of Science and Higher Education of the Russian Federation 075-15-2019-1669Russian Science Foundation 22-15-00462
6 · The paper itselfAbstract
High-grade serous ovarian carcinoma (HGSOC) remains the most common and deadly form of ovarian cancer. However, available cell lines usually fail to appropriately represent its complex molecular and histological features. To overcome this drawback, we established OVAR79, a new cell line derived from the ascitic fluid of a patient with a diagnosis of HGSOC, which adds a unique set of properties to the study of ovarian cancer. In contrast to the common models, OVAR79 expresses
Indexed as
Cell ProliferationCystadenocarcinoma, SerousOvarian NeoplasmsPTEN PhosphohydrolaseCell Line, TumorCell MovementClass I Phosphatidylinositol 3-KinasesFemaleHumansMutationNeoplasm GradingTumor Suppressor Protein p53Class I Phosphatidylinositol 3-KinasesPIK3CA protein, humanPTEN PhosphohydrolasePTEN protein, humanTumor Suppressor Protein p53cell linehigh-grade serous ovarian cancerovarian cancer
Identifiers
PMID39769003
PMCPMC11676670
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