Evidence mapPaperPMID 39769006Full record

ArticleInternational journal of molecular sciences2024

Assessing Cytotoxicity, Proteolytic Stability, and Selectivity of Antimicrobial Peptides: Implications for Orthopedic Applications.

Davide Campoccia, Giulia Bottau, Andrea De Donno, Gloria Bua, Stefano Ravaioli, Eleonora Capponi, Giovanna Sotgiu, Chiara Bellotti, Silvia Costantini, Carla Renata Arciola

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Special Issue "Natural Compounds: Advances in Antimicrobial Activity".International journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Davide CampocciaLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.ORCID 0000-0002-3336-0219
Giulia BottauLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
Andrea De DonnoLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.ORCID 0009-0008-4401-2149
Gloria BuaLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
Stefano RavaioliLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.ORCID 0000-0001-5364-6196
Eleonora CapponiLaboratorio di Patologia delle Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.
Giovanna SotgiuInstitute for Organic Synthesis and Photoreactivity (ISOF), National Research Council, Via Gobetti 101, 40129 Bologna, Italy.ORCID 0000-0003-3590-714X
Chiara BellottiOsteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies Unit, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, 40136 Bologna, Italy.ORCID 0000-0001-9900-7357
Silvia CostantiniDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
Carla Renata ArciolaDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.ORCID 0000-0003-0382-0066

Funding

APC by BUS24Q7_PATOBIOCLINICA-BUS24 for Postgraduate Medical School of Clinical Pathology and Clinical Biochemistry of the University of Bologna. BUS24Q7_PATOBIOCLINICA-BUS24
6 · The paper itself

Abstract

In orthopedics, the use of anti-infective biomaterials is considered the most promising strategy to contrast the bacterial contamination of implant surfaces and reduce the infection rate. KSL, KSL-W, and Dadapin-1 are three antimicrobial peptides (AMPs) that possess significant antibacterial properties, making them promising candidates for producing anti-infective biomaterials not based on antibiotics. To fully assess their true potential, this study explores in detail their cytocompatibility on human osteoblast-like MG63 cells, murine fibroblastoid L929 cells, and hMSCs. To this end, the cytotoxicity of the AMPs in terms of IC

Indexed as

Antimicrobial PeptidesAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCell LineCell SurvivalHumansMiceMicrobial Sensitivity TestsOrthopedicsOsteoblastsProteolysisAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAMPsantimicrobial peptidescytocompatibilitycytotoxicityhMSCsimplant orthopedic infectionsL929MG63proteolytic stabilityselectivity index

Identifiers

PMID39769006
PMCPMC11678430

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.