Evidence map›Paper›PMID 39769010›Full record

ArticleInternational journal of molecular sciences2024

Extracellular PKM2 Preserves Cardiomyocytes and Reduces Cardiac Fibrosis During Myocardial Infarction.

Yang Huang, Bin Li, Zongxiang Gui, Erhe Gao, Yi Yuan, Jenny Yang, Khan Hekmatyar, Falguni Mishra, Payton Chan, Zhiren Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Rewiring the scar: translational advances in cardiac fibrosis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang HuangDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-1873-1675
Bin LiDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Zongxiang GuiDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Erhe GaoCenter for Translational Medicine, Temple University, Philadelphia, PA 19140, USA.
Yi YuanDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Jenny YangDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-2310-7658
Khan HekmatyarDepartment of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
Falguni MishraDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.
Payton ChanDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.ORCID 0009-0001-1744-2265
Zhiren LiuDepartment of Biology, Georgia State University, Atlanta, GA 30303, USA.ORCID 0000-0002-2460-1631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substantial loss of cardiomyocytes during heart attacks and onset of other cardiovascular diseases is a major cause of mortality. Preservation of cardiomyocytes during cardiac injury would be the most effective strategy to manage these diseases in clinic. However, there is no effective treatment strategy that is able to prevent cardiomyocyte loss. We demonstrate here that the systemic administration of a recombinant PKM2 mutant (G415R) preserves cardiomyocytes and reduces cardiac fibrosis during myocardial infarction. G415R preserves cardiomyocytes by protecting the cardiomyocytes from dying and by promoting cardiomyocyte proliferation. Preservation of cardiomyocytes by extracellular PKM2 (EcPKM2) reduces cardiac fibrosis because of the decreased activation of cardiac fibroblasts. Our experiments show that EcPKM2 (G415R) exerts its action by interacting with integrin a

Indexed as

Cell ProliferationFibrosisMyocardial InfarctionMyocytes, CardiacAnimalsApoptosisFocal Adhesion Kinase 1Integrin alphaVbeta3MaleMiceOxidative StressPhosphatidylinositol 3-KinasesPyruvate KinaseRatsSignal TransductionThyroid Hormone-Binding ProteinsFocal Adhesion Kinase 1Integrin alphaVbeta3Phosphatidylinositol 3-KinasesPkm protein, mousePyruvate KinaseThyroid Hormone-Binding ProteinsThyroid Hormonescardiomyocytesintegrin αvβ3myocardial infarctionpyruvate kinase M2

Identifiers

PMID39769010
PMCPMC11675365

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.