Evidence map›Paper›PMID 39769109›Full record

ArticleInternational journal of molecular sciences2024

Exploring the Interplay of Gut Microbiota and Systemic Inflammation in Pediatric Obstructive Sleep Apnea Syndrome and Its Impact on Blood Pressure Status: A Cross-Sectional Study.

Chung-Guei Huang, Wan-Ni Lin, Li-Jen Hsin, Tuan-Jen Fang, Hsueh-Yu Li, Chin-Chia Lee, Li-Ang Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chung-Guei HuangDepartment of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.ORCID 0000-0002-0598-5684
Wan-Ni LinDepartment of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan.ORCID 0000-0001-5782-8835
Li-Jen HsinDepartment of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan.ORCID 0000-0001-9201-0270
Tuan-Jen FangDepartment of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan.ORCID 0000-0002-7805-3458
Hsueh-Yu LiDepartment of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan.ORCID 0000-0002-9016-8098
Chin-Chia LeeSchool of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Li-Ang LeeDepartment of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan.ORCID 0000-0001-8414-595X

Funding

National Science and Technology Council, Taiwan 109-2314-B-182-083-MY3
6 · The paper itself

Abstract

Obstructive sleep apnea syndrome (OSAS) is prevalent among children and is associated with elevated blood pressure (BP), posing a risk for future hypertension and cardiovascular diseases. While the roles of gut microbiota and systemic inflammation in OSAS pathogenesis are recognized in adults and animal models, their impact on pediatric BP remains less understood. This cross-sectional study explored the relationships between polysomnographic parameters, gut microbiota, systemic inflammation, and BP in 60 children with OSAS. Significant associations between specific microbial profiles-including beta diversity and 31 marker microbes-and BP variations were observed. These microbial profiles correlated with significant alterations in systemic inflammation markers like interleukin-17 and tumor necrosis factor-α. Notably, the relative abundance of

Indexed as

InflammationSleep Apnea, ObstructiveBiomarkersBlood PressureChildChild, PreschoolCross-Sectional StudiesFemaleHumansInterleukin-17MalePolysomnographyTumor Necrosis Factor-alphaBiomarkersInterleukin-17TNF protein, humanTumor Necrosis Factor-alphablood pressuregut microbiotainterleukin-17obstructive sleep apnea syndromesystemic inflammationtumor necrosis factor-α

Identifiers

PMID39769109
PMCPMC11727798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.